摘要
目的:研究水芹正丁醇提取物的抗凝血和抗血栓作用。方法:分别通过玻片、毛细管、剪尾法研究水芹正丁醇提取物对小鼠凝血时间、尾出血时间的影响;用Chandler法及动-静脉旁路法研究水芹正丁醇提取物对家兔体外血栓和动-静脉旁路血栓形成的影响;同时用Wright法研究水芹正丁醇提取物对家兔血小板黏附功能的影响。结果:水芹正丁醇提取物(500、250mg/(kgbw·d))能明显延长小鼠凝血时间和出血时间;水芹正丁醇提取物(280、140mg/(kgbw·d))能明显抑制家兔体外血栓和动-静脉旁路血栓的形成,在同样剂量下,能明显抑制家兔的血小板黏附功能。结论:水芹正丁醇提取物具有抗凝血和抗血栓形成作用。
Objectives：To investigate anti-coagulation and anti-thrombosis effects of n-butanol extract from Oenanthe aquatic.Methods：The effect of n-butanol extract from Oenanthe aquatic on coagulation time and bleeding time of mouse tails was investigated using glass coverslip,capillary and cutting tail methods.Meanwhile,the effect of n-butanol extract from Oenanthe aquatic on thrombosis and thrombosis of arterio-venous bypass in rabbits was studied using Chandle and arterio-venous bypass methods.In addition,the effect of n-butanol extract from Oenanthe aquatic on platelet adhesion function in rabbits was also studied using Wright method.Results：n-butanol extract from Oenanthe aquatic at the doses of 500 mg/（kg bw·d）and 250 mg/（kg bw·d） significantly prolonged coagulation time and bleeding time in mice.When the dose was 280 or 140 mg/（kg bw·d）,thrombosis and thrombosis of arterio-venous bypass in rabbits were significantly inhibited and a significant inhibitory effect on platelet adhesion function in rabbits was observed.Conclusion：n-butanol extract from Oenanthe aquatic has anti-coagulation and antithrombosis effects.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2010年第7期280-283,共4页
Food Science
关键词
水芹正丁醇提取物
凝血时间
出血时间
血栓形成
血小板黏附
n-butanol extract from Oenanthe aquatic
coagulation time
bleeding time
thrombosis
platelet adhesion
