摘要
目的:探讨微血管密度(MVD)、基质金属蛋白酶-2(MMP-2)和MMP-9在肝细胞肝癌转移中的作用及其各自和预后的相关性。方法:以石蜡包埋组织切片,免疫组化SP法染色分别检测97例肝细胞肝癌MVD和MMP-2、MMP-9表达的情况,其中复发与转移组49例,非复发与转移组48例。结果:转移组MVD高于无转移组(P=0.015),转移组MMP-2和MMP-9表达高于无发转移组(P=0.009,P=0.043),差异具有统计学意义。结论:MVD增高、MMP-2和MMP-9过度表达可能与肝细胞肝癌转移、不良生存预后存在相关性。
Objective： To investigate the effect of microvessel density and expression of MMP-2 and MMP-9 on the metastasis of hepatocellular carcinoma and their correlation with patients＇ prognosis. Methods： Immunohistochemistry （SP） was employed to detect MVD and expression of MMP-2 and MMP-9 in 97 samples of hepatocellular carcinoma. There were 49 cases with metastasis and 48 cases with no metastasis. Results： The abnormal MVD and expression of MMP-2 and MMP-9 in cases with metastasis were higher than those in cases with no metastasis （P=0.015; P=0.009）. Conclusion： Abnomal MVD and expression of MMP-2 and MMP-9 may play an important role in the metastasis of hepatocellular carcinoma and indicate poor prognosis.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2010年第7期385-387,共3页
Chinese Journal of Clinical Oncology
基金
天津市应用基础及前沿技术研究计划重点项目(编号:08JCZDJC23500)
天津市应用基础及前沿技术研究计划面上项目(编号:09JCYBJC12100)
天津市科技支撑项目(中瑞国际合作)资助(编号:09ZCZDSF04400)~~
