摘要
目的探讨肿瘤新生血管形成在胃癌进展中的作用。方法利用抗人因子Ⅷ相关抗原（Ｆ－ⅧＲＡｇ）抗体的免疫组织化学ＬＳＡＢ法，对１３１例胃癌患者手术切除标本中微血管进行定量。计数２００×视野下５个最高血管密度区的微血管数（ＭＶＣ），取其均数，分析ＭＶＣ与不同临床病理因素及预后之间的关系。结果ＭＶＣ随ＴＮＭ分期而增加（Ｐ＜０．０１）。ＭＶＣ与癌组织浸润的深度（Ｐ＜０．０５）、淋巴结转移（Ｐ＜０．０１）和远处转移（Ｐ＜０．０５）有关。高ＭＶＣ组（ＭＶＣ≥１６）根治术的复发率（５８．４％）明显高于低ＭＶＣ组（ＭＶＣ＜１６）的复发率（２９．７％）（Ｐ＜０．０５），高ＭＶＣ患者预后较低ＭＶＣ者差（Ｐ＜０．０５），５年生存率可通过Ｐ＝ｅ１．６２３１－０．１０３６·ＭＶＣ１＋ｅ１．６２３１－０．１０３６·ＭＶＣ进行估算。多因素分析表明，ＭＶＣ是胃癌的一个独立预后因子。结论胃癌组织内的ＭＶＣ是预测肿瘤恶性行为的一个有用指标。
Objective To determine whether tumor angiogenesis correlates with progression of gastric carcinoma. Method Microvessel counts (MVC) of 131 specimens resected from patients with gastric carcinoma were investigated by immunohistological staining with a monoclonal antibody against F Ⅷ RAg, counting the mean number of microvessels in the five areas of highest vascular density under 200 times magnification microscopy. Correlation among MVC, various clinicopathologic factors, and prognosis was studied. Result MVC increased with TNM stage, the MVC of patients with advanced stage disease was significantly higher than that of early stage patients ( P <0 01). MVC was significantly higher in tumors with deep penetration ( P <0 05), lymph node metastasis ( P <0 001) and distant metastasis ( P <0 05) than in those without invasion and such metastasis. The recurrence rate after curative resection in hypervascular group(MVC≥16) was 58 4%, which was significantly higher ( P <0 05) than that in the hypovascular group(MVC<16). Moreover, the prognosis of patients with a high MVC was significantly poorer than that of those with a low MVC. The probability of 5 year survival rate was estimated by P=e 1 6231-0 1036·MVC 1+e 1 6231-0 1036·MVC . Multivariate analysis indicated that MVC is an independent prognostic factor in gastric cancer. Conclusion Angiogenesis within gastric cancer is an indicator of tumor behavior and may identify patients at higher risk for recurrence and poorer prognosis.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1998年第5期307-309,I057,共4页
Chinese Journal of Surgery
关键词
胃肿瘤
新生血管化
预后
Stomach neoplasms Neovascularization prognosis
