摘要
目的：检测淋巴结内非霍奇金淋巴瘤Ｐ５３蛋白的表达，探讨其意义。方法：常规ＨＥ染色进行组织学分类，利用免疫组织化学ＬＳＡＢ法确定肿瘤的免疫表型、检测淋巴瘤中Ｐ５３蛋白的表达水平。结果：６０例非霍奇金淋巴瘤中，Ｐ５３蛋白阳性３２例（５３．３％）。其中，低度恶性３８例，Ｐ５３蛋白阳性１８例（４７．４％）；高度恶性２２例，Ｐ５３蛋白阳性１４例（６３．６％）。１０例淋巴结反应性增生Ｐ５３蛋白均为阴性。结论：Ｐ５３蛋白的积聚在非霍奇金淋巴瘤的发生发展过程中可能起着一定作用；Ｐ５３蛋白表达的阳性程度及阳性率可能与非霍奇金淋巴瘤的恶性度有关；
Objective:To study the expression of P53 and its significance in non Hodgkin′s lymphoma.Methods:HE Stain was used for histopathologic classification,and immunohistochemistry for immunophenotype to detect protein P53.Results:The positive rate of P53 protein was found 53 3% (32/60 cases).Low grade lymphoma (18/38) was positive for P53 protein (47.4%),and high grade lymphoma (14/22) was positive (63.6%).In 10 cases of reactive hyperplasia of lymph node tissue,protein P53 was negative.Conclusion:P53 protein may play an important role in the pathogenesis of non Hodgkin′s lymphoma.The positive degree of P53 might be an index for evaluating the malignant degree of non Hodgkin′s.To reactive hyperplasia of lymph node tissue P53 protein was negative.
出处
《山西医药杂志》
CAS
1999年第3期210-211,共2页
Shanxi Medical Journal
