摘要
目的研究生物膜在实验性小梁切除术中防止滤过道粘连的作用。方法将生物膜植入家兔小梁切除术的巩膜瓣及结膜瓣下，同一只家兔的另一只眼术中未植入生物膜作为对照眼，进行滤过泡、眼压及组织学观察。结果（１）创伤后的修复过程于术后２～３周达到高峰，而生物膜在术后６周以后开始吸收，生物膜与瘢痕组织间不发生紧密粘连，从而保持滤过道通畅。（２）术后２～７周，实验组功能性滤过泡存留比率明显高于对照组（Ｐ＜０．０５）。（３）术后１～５周，实验组眼压明显低于对照组（Ｐ＜０．０５）。结论生物膜可以在家兔小梁切除术中起到防止滤过泡粘连、有效地保证降低眼压的作用，将为临床研究提供动物实验基础。
Objective The study was designed to investigate the effects of biomembrane on experimental trabeculectomy.Methods A biomembrane was implanted under the scleral flap and the conjunctival flap in trabeculectomy in one eye of rabbits, while the fellow eye of the same rabbit without biomembrane implantation was the control. Results (1) The wound healing of the procedure reached its peak at 2 3 weeks after surgery, while the absorption of the biomembrane began at 6 weeks after surgery, and there was no tight adhesion between the biomembrane and the scar tissue, thus the filtering fistula was prevented from obstruction. (2) From the 2nd to the 7th week after surgery, the percentage of existing functional bleb in the experimental group was significantly higher than that in the control group ( P <0.05). (3) From the 1st to the 5th postoperative week, the decreasing of intraocular pressure in the experimental group was significantly greater than that in the control group ( P <0.05). Conclusion The use of biomembrane in trabeculectomy can prevent the adhesion of filtering bleb and decrease intraocular pressure more effectively, and this study can provide experimental reference for the clinical use of biomembrane.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
1998年第1期68-70,I005,共4页
Chinese Journal of Ophthalmology
关键词
青光眼
小梁切除术
生物膜
滤过泡
动物实验
Glaucoma Trabecular meshwork Biomembrane Filtering bleb Experiment, animal
