摘要
目的:比较复方锌布颗粒(臣功再欣)和对乙酰氨基酚(百服宁)对治疗小儿急性呼吸道感染伴发热的退热效果,为临床选择有效安全口服退热药提供参考。方法:选择有急性呼吸道感染伴发热患儿118例,并随机分为两组。治疗组72例给予复方锌布颗粒10mg/(kg.次)口服;对照组46例给予对乙酰氨基酚0.4ml/(kg.次)口服。结果:两组在服药后2小时内退热总有效率分别为100%和97.8%,差异无统计学意义(P>0.5),但治疗组60分钟体温下降幅度明显大于对照组(t=2.76,P<0.05),最大作用时间及退热持续时间均差异有显著性(t=3.25和5.01,P均<0.01)。结论:复方锌布颗粒和对乙酰氨基酚退热效果确切,但复方锌布颗粒退热作用更强更快,维持时间也长,并且安全。
Objective：To compare the effectiveness of Compound Zinc GIuconate and Ibuprofen Granules and Acetaminophen in the treatment of childrens fever which is initiated by acute respiratory tract infection, so as to provide a reference for an effective and safe clinical treatment on oral antipyretics. Method： Randomly grouped 118 children, suffering from acute respirator）, infections with fever, into two groups. 72cases in the treatment group were treated with oral Compound Zinc Gluconate and Ibuprofen Granules, 10mg/kg at a once. The other 46 cases in the control group were given oral Acetaminophen, 0. 4ml/kg at a once. Results： Within2h after taking the antipyretics, the antipyretic effective rates between these two groups respectivelywere100% and97. 8%, andthenostatisticalsignificancewasa. However,within 60min in the treatment group childrens body temperature dropped significantlyfaster than that in the control group, and the maximum effective time and the duration of fever dropping in the groups were conspicuously different. Conclusion： Both Compound Zinc Gluconate and Ibuprofen Granules and Acetaminophen have exact antipyretic effect. Comparatively, Compound Zinc Gluconate and Ibuprofen Granules can reduce fever in a faster, more effective, more durable and safer way.
关键词
复方锌布颗粒
对乙酰氨基酚
儿童发热
Compound Zinc Gluconate and Ibuprofen Granules
Acetaminophen
children
fever
