摘要
目的：探讨肾细胞癌与多药耐药的关系。方法：应用免疫组化方法，检测４４例术前未进行化疗的肾细胞癌和１６例正常肾组织中的Ｐ糖蛋白（Ｐ－ｇｐ）和谷胱甘肽－Ｓ－转移酶－π（ＧＳＴ－π）表达。结果：Ｐ－ｇｐ和ＧＳＴ－π在１６例正常肾组织中的表达率均为１００％，在４４例肾细胞癌组织中分别为６３．６％和５４．５％，Ｐ－ｇｐ和／或ＧＳＴ－π阳性表达率为７９．５％。Ｐ－ｇｐ和ＧＳＴ－π的表达与其组织类型有关，与肿瘤的分化程度无关。结论：检测Ｐ－ｇｐ和ＧＳＴ－π对肾细胞癌病人的治疗方案选择和预后判断具有重要的临床意义。
Purpose To study the correlation of renal cell carcinoma and multidrug resistance. Methods Fortyfour human renal cell carcinomas of previously untreated patients and 16 normal kidney tissues were studied for the expression of Pglycoprotein(Pgp) and glutathione Stransferaseπ (GSTπ) by means of immunohistochemistry. Results The expressions of Pgp and GSTπ were 100% in the proximal tubules of the kidney, 636% and 545% in renal cell carcinoma tissues, respectively. The expressions of Pgp and/or GSTπ were 795%. There was a correlation between the expression of Pgp/GSTπ and histologic subtypes, but no difference in grades of differentiation in renal cell carcinomas. Conclusions Pgp and GSTπ may have significant clinic value in the evaluation of prognosis and therapy design.
出处
《临床与实验病理学杂志》
CAS
CSCD
1998年第2期131-133,I019,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
肾肿瘤
肾细胞癌
P糖蛋白
GST-Π
kidney neoplasms
carcinoma,renal cell
glutathione transferases
drug tolerance
immunohistochemistry
