摘要
目的：研究卵巢有梭形细胞成分宫内膜样癌伴肝样癌的临床病理特征以及肝样癌的组织发生。方法：收集和分析病人的临床病理资料。石蜡切片免疫组化ＡＢＣ法染色。结果：①１例６２岁老妇，患有原发性高度恶性卵巢癌，并伴有ＡＦＰ明显升高。ＡＦＰ常随病情变化而变化；②病理特征主要为有梭形细胞成分宫内膜样癌和明显肝样癌成分。免疫组化染色显示肝样癌及其癌细胞内外玻璃小体ＡＦＰ阳性；内膜样癌中腺上皮Ｋｅｒａｔｉｎ、ＥＭＡ、ＥＲ阳性；而梭形细胞则Ｋｅｒａｔｉｎ、ＥＭＡ和Ｖｉｍ阳性。而Ｄｅｓｍｉｎ、Ｍｙｏｇｌｏｂｉｎ、ＧＡＦＰ、ＨＣＧ所有瘤细胞均为阴性；③由于ＡＦＰ具有免疫抑制作用，患者预后不良。结论：以上结果表明，有梭形细胞成分卵巢宫内膜样癌伴肝样癌为卵巢一种特殊临床病理实体。
Purpose To study the clinicopathological features of one case of endometrioid carcinoma of the ovary with spindle cells component and hepatoid carcinoma and histogenesis of hepatoid carcinoma. Methods The patient's clinicopathological data were collected. Studies were carried out according to the avidinbiotinperoxidase complex (ABC) technique. Results (1)A 62yearold woman patient with primary high malignant neoplasm of the ovary with extremely high alphafetoprotein (AFP) level (4767 μg/L) was described. (2)The main components of the tumor were endometrioid glands with the spindle cells and foci of squamous metaplasia and foci strongly resembling hepatocellular carcinoma with hyaline globules (HGs) were noted on HE staining and immunochemical staining for AFP, showing the production of AFP by tumor cells themselves. They were found both extracellualrly and intracellularly. (3)The glandular epithelium were stained for keratin, EMA, and ER. Keratin, EMA and Vim were identified in spindle cells. Spindle cells were negative for Desmin, Myoglobin, GFAP, HCG. (4) The patient had poor prognosis because AFP had an immunosuppressive effect. Conclusions The results suggest that the tumor may constitute a specific clinicopathological entity, it is an endometrioid carcinoma of the ovary with spindlecell compinent and hepatoid carcinoma and it may transform into hepatoid carcinoma after recurrence.
出处
《临床与实验病理学杂志》
CAS
CSCD
1998年第1期55-57,I010,共3页
Chinese Journal of Clinical and Experimental Pathology
关键词
卵巢肿瘤
宫内膜样癌
肝样癌
甲胎蛋白
病理学
ovarian neoplasms
endometrioid carcinoma
hepatoid carcinoma
alphafetoproteins
