摘要
目的探讨原发性异位脑膜瘤的临床病理特点、诊断及鉴别诊断依据。方法对4例原发性异位脑膜瘤临床病理资料进行回顾性分析。结果4例原发性异位脑膜瘤中女性3例,男性1例,发病年龄23～71岁,发生部位分别为右额部皮下、左侧鼻腔、右肺上叶及左耳中鼓室。4例原发性异位脑膜瘤中,脑膜上皮细胞型2例,过渡型1例,脑膜上皮细胞型与血管瘤型混合1例。免疫组织化学染色示4例瘤细胞均表达Vim及EMA,1例部分瘤细胞表达S-100蛋白,均不表达CK、GFAP、NF、CD34、Actin、SMA、Desmin、Syn、CgA及CEA。随访患者均无复发。结论原发性异位脑膜瘤是一种少见的良性肿瘤,容易误诊。根据其组织病理学特征,结合免疫组织化学染色结果可以作出明确诊断。
Objective To review the clinicopathological characteristics,diagnosis and differential diagnoses of primary ectopic meningioma.Methods Four cases of primary ectopic meningioma during 2006-2009 were reviewed retrospectively.Results One patient was male and 3 were female.Ages of the patients ranged from 23 to 71 years.The sites of the tumor involvement were subcutaneous,nasal cavity,lung and middle ear.Histopathologically,2 cases were meningothelial type,1 was transitional type and another was both meningothelial and angiomatous type.Immunohistochemically,the tumor cells were positive for vimentin（4/4）,EMA（4/4）and S-100 protein（1/4）,but were negative for CK,GFAP,NF,CD34,Actin,SMA,Desmin,Syn,CgA and CEA.Four patients remained alive free of disease.Conclusion Primary ectopic meningioma is a rare benign tumor;the definitive diagnosis relies on its histopathological characteristics and immunohistochemical findings.
出处
《实用肿瘤杂志》
CAS
北大核心
2010年第2期211-213,共3页
Journal of Practical Oncology
关键词
脑膜瘤/病理学
脑膜瘤/诊断
回顾性研究
免疫组织化学
诊断
鉴别
meningioma/pathology
meningioma/diagnosis
retrospective studies
immunohistochemistry
diagnosis
differential
