摘要
目的研究回族健康志愿者单次静脉滴注盐酸头孢吡肟后的药动学,并与汉族健康志愿者的药动学进行比较。方法回族和汉族健康志愿者各10名,男女各半,单次静脉滴注盐酸头孢吡肟1.0g,定时采血,用高效液相色谱法测定头孢吡肟的血药浓度,用DAS2.0软件进行数据处理,用SPSS11.5软件进行统计分析。结果两组药动学参数分别为:Cmax为(62.91±10.69)、(68.75±10.41)mg/L;t1/2β为(1.94±0.24)、(1.97±0.20)h;AUC(0-10.5)为(129.48±23.02)、(136.89±23.02)mg.h/L;AUC(0-∞)为(132.78±23.79)、(139.69±23.78)mg.h/L。结论头孢吡肟的药代动力学在回、汉两民族无种族差异。
Objective To investigate the pharmacokinetics of cefepime after a single intravenous administration in Chinese healthy Muslim and Han volunteers.Methods Ten Chinese healthy Muslim volunteers and ten Chinese healthy Han volunteers were involved in the study. Each subject received a single dose of 1.0 g cefepime hydrochloride. The plasma concentration was determined by high performance liquid chromatography method. The pharmacokinetic parameters were calculated by DAS2.0 software and were compared by SPSS11.5 software.Results The main pharmacokinetic parameters of the two ethnic groups were as follows：Cmax was（62.91±10.69）,（68.75±10.41） mg/L;t1/2βwas（1.94±0.24）,（1.97±0.20） h;AUC（0-10.5） was（129.48±23.02）,（136.89±23.02） mg·h/L;AUC（0-∞） was（132.78±23.79）,（139.69±23.78） mg·h/L.Conclusion The ethnic difference between Chinese Muslim and Chinese Han does not affect the pharmacokinetics of cefepime.
出处
《解放军药学学报》
CAS
2010年第2期110-112,共3页
Pharmaceutical Journal of Chinese People's Liberation Army
基金
全军医学科学技术研究"十一五"计划科技攻关课题基金资助项目
No.06G023
关键词
头孢吡肟
高效液相色谱法
药动学
回族
汉族
cefepime
high performance liquid chromatography
pharmacokinetics
Chinese Muslim
Chinese Han
