摘要
目的:确定甘肃地区汉族人群中细胞色素P4502C19(CYP2C19)的基因型及等位基因分布特征,并考察性别对其多态性的影响。方法:选取甘肃地区无亲缘关系汉族健康人,采用多聚酶链反应-限制性片段长度多态性(PCR-RFLP)法分析CYP2C19基因多态性。结果:检测到CYP2C19的6个基因型,其分布在男女间无显著性差异。结论:在甘肃地区汉族人群中,CYP2C19的基因型分布与其他地区一致,而性别对其多态性无显著影响。
OBJECTIVE：To identify the genotype and allele distribution feature of cytochrome P4502C19（CYP2C19）in Han population from Gansu and investigate the effects of gender on genetic polymorphism of CYP2C19. METHODS：Healthy Han subjects without genetic relationship one another were enrolled and PCR- RFLP assay was used to analyze the genetic polymorphisms of CYP2C19. RESULTS：No significant difference in six genotypes of CYP2C19 was observed between male and female. CONCLUSION：The genotype distribution of CYP2C19 in Han population from Gansu is similar to that of people in other area. Gender has no significant effect on genetic polymorphisms of CYP2C19 in Han population from Gansu.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第14期1285-1287,共3页
China Pharmacy
