摘要
目的确定细胞色素P450 2C19(CYP2C19)在甘肃地区回族藏族人群中的基因型及等位基因分布特征,并考察性别对其基因多态性的影响。方法选取甘肃地区回族藏族无亲缘关系的健康人,采用多聚酶链反应-限制性片段长度多态性(PCR-RFLP)法分析CYP2C19基因多态性。结果检测到CYP2C19的5个基因型,其在男女间分布差异无统计学意义,但在回族藏族间分布差异有统计学意义(P<0.05)。结论在甘肃地区回族藏族健康人群中,CYP2C19的基因型分布差异有统计学意义,而性别对CYP2C19遗传多态性无显著影响。
Objective To identify the genotype and allele distribution feature of cytochrome P450 2C19（CYP2C19）in Chinese Hui and Zang populations of Gansu,and investigate the effects of gender on genetic polymorphism of CYP2C19 in the populations.Methods The CYP2C19 genotype of unrelated healthy Chinese Hui and Zang population subjects were assessed by polymerase chain reaction and restriction fragment length polymorphism（PCR-RFLP）.Results Five different CYP2C19 genotypes were observed in this study.There was no significant difference between male and female,but significant difference between the two Chinese populations（P0.05）.Conclusion Population has significant effect on genetic polymorphism of CYP2C19 in Chinese Hui and Zang populations of Gansu,and the effect on gender is not significant.
出处
《实用药物与临床》
CAS
2010年第2期95-97,共3页
Practical Pharmacy and Clinical Remedies
