摘要
目的观察乳腺癌术前化疗的临床和病理改变，判断药物疗效，指导术后治疗。方法对术前化疗手术标本进行ＨＥ、免疫组织化学染色观察。结果和术前未化疗的对照组相比，乳腺癌化疗后出现瘤体变软缩小、肿瘤细胞退变坏死、间质水肿、血管周围炎症细胞浸润及异物肉芽肿形成等改变；免疫组织化学显示ＰＣＮＡ、ＣｅｒｂＢ２蛋白阳性表达明显降低。ＥＲ、ＰＲ表达无显著差异。结论乳腺癌术前化疗在降低肿瘤细胞增殖活力，使瘤体缩小。
Objective To observe the clinical and pathological changes of breast carcinomas after preoperative chemotherapy.Methods HE section staining and immunohistochemical labelling were used.Results The specimen after chemotherapy showed the tumor in most of the cases regressed; the tumor cells were degenerative and necrotic. The stromal edema and infiltration of inflammatory cells near the vessels in some cases, calcification and granuloma in a few cases were found. The immunohistochemical stainings showed significant lower expression in PCNA and C erbB2 protein compared with that of the control group.Conclusion The preoperative chemotherapy has the actions of promoting tumor regression and decreasing its proliferative activity to avoid spreading during an operation, in the mean time the opportunity of conservative treatment for the tumor is increased.
出处
《诊断病理学杂志》
CSCD
1998年第3期135-137,共3页
Chinese Journal of Diagnostic Pathology
关键词
乳腺癌
术前化疗
病理形态学
Breast carcinoma Preoperative chemotherapy
