摘要
目的利用Meta分析方法对丹红注射液治疗脑梗死的临床研究进行合并分析,评价其治疗脑梗死的临床效果。方法按照循证医学的要求,全面检索中国期刊全文数据库、中国博硕士学位论文全文数据库及PubMed数据库等,把符合纳入标准的45篇文献作为Meta分析的对象。采用Cochrane协作网免费提供的RevMan4.2.2(ReviewManager)专用软件进行统计分析。结果45项研究经Meta分析合并,结果显示,同质性检验:χ2=26.32(自由度为44),P=0.98(P>0.10),表明45项研究具有同质性。固定效应模型的Peto法进行分析计算,合并比值比:OR合并=3.14,95%CI为[2.65,3.73],χ2=13.06(P<0.01)。结论现有的临床证据表明,丹红注射液治疗脑梗死的疗效优于目前临床的常用药物,实验组与对照组不良反应发生率均较低。
Objective To evaluate the effect of Danhong injection on cerebral infarction by meta analysis.Methods According to the requirements of evidence-based medicine,45 articles（randomized controlled trials）about effect of Danhong injection on treating cerebral infarction were searched from Chinese periodical full-text database,Chinese doctoral dissertations master＇s theses full-text database,and PubMed database.Therapeutic effects on cerebral infarction were selected as the study indexes.RevMan 4.2.2（Review manager）software provided by Cochrane collaboration net was applied for data processing and statistical analysis.Results Testing homogeneity of 45 literatures showed that the adopted articles possessed the characters of homogeneity（χ2=26.32,df=44,P=0.98）,and the results of Peto method of a fixed-effect model were as follows：ORmerge=3.14,95% CI[2.65,3.73],χ2=13.06,P0.01.Conclusion From the existing clinical evidences,Danhong injection is more effective than other drugs used routinely in treating cerebral infarction.
出处
《实用药物与临床》
CAS
2010年第2期98-100,共3页
Practical Pharmacy and Clinical Remedies
关键词
丹红注射液
脑梗死
META分析
Danhong injection
Cerebral infarction
Meta-analysis
