摘要
目的探讨葡萄籽提取物对人体的抗氧化作用。方法将106例年龄在45～65岁之间的健康志愿者按血清丙二醛含量随机分为试食组和对照组,受试组连续服用受试物180d。测定血清中丙二醛(MDA)含量及超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性和安全性指标。结果试食后试食组丙二醛含量明显下降,下降率为5.91%;超氧化物歧化酶活性明显升高,与对照组试食后及自身试验前后比较差异均有统计学意义(P<0.05),升高率为17.41%;谷胱甘肽过氧化物酶活性明显升高,升高率为7.37%。各项安全性指标试验前后均无明显改变。结论葡萄籽提取物对人体具有抗氧化作用。
Objective To explore the antioxidant effect of grape seed extract on human body.Methods Totally 106 healthy volunteers aged from 45 to 65 years were divided into test group and control group randomly according to the content of serum MDA.The volunteers in test group were given the grape seed extract capsules for 180 days.The content of MDA,the activities of SOD and GSH-Px,and the indexes of safety were determined at the end of 180 days.Results The content of serum MDA in test group was decreased significantly,with the decreasing rate of 5.91%.The activity of SOD in test group was increased significantly,with the increasing rate of 17.41%.There were statistically significant differences in the activity of SOD between test group and control group,as well as in test group between before and after experiment （P0.05）.The activity of GSH-Px in test group was increased significantly,with the increasing rate of 7.37%.All kinds of indexes of safety did not change before and after the experiment.Conclusions Grape seed extract has the antioxidant effect on human body.
出处
《实用预防医学》
CAS
2010年第4期757-759,共3页
Practical Preventive Medicine
