摘要
目的采用无创性技术经咽鼓管鼓室内导入造影剂钆，进行内耳三维快速液体衰减反转恢复磁共振扫描（three dimensional fluid attenuated inversion recovery magnetic resonance imaging,3D-FLAIR MRI）,，探讨梅尼埃病内淋巴间隙的显像。方法7例梅尼埃病患者患侧经咽鼓管鼓室内导人钆喷酸葡胺稀释液，24h后进行内耳3D．FLAIRMRI。全部患者于造影剂导入前、导人后24h及3个月时分别进行纯音测听和鼓室声导抗检查。结果5例患者内耳3D—FLAIRMRI显示造影剂钆广泛分布于患侧耳蜗、前庭和（或）半规管的外淋巴，可以区分内、外淋巴间隙的边界，清晰显像内淋巴情况；2例患者患侧包围内淋巴的外淋巴间隙缩小或消失（即不显影），提示内淋巴积水的存在。5例患侧中耳鼓室腔内未见造影剂钆增强；2例患侧部分中耳乳突腔内可见造影剂钆增强，而内耳未见明显增强。所有患者造影剂给药前和给药后24h纯音测听平均听阈无明显变化；给药前、给药后24h及3个月时鼓室声导抗结果无明显变化。结论经咽鼓管鼓室内导入造影剂钆进行内耳3D—FLAIRMRI扫描，可以了解梅尼埃病患者内淋巴间隙情况。
Objective To visualize the endolymph in Meniere＇s disease by applying for non- invasive intratympanic gadolinium through eustachian tube and three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging （3D-FLAIR MRI）. Methods With a 3 Tesla magnetic resonance imaging （MRI） unit, 3D-FLAIR imaging was performed 24 h after intratympanic gadolinium through eustachian tube in seven patients with Meniere＇s disease. Pure tone test was performed 24 h before and after administered gadolinium. Tympanometry was performed 24 h before, 24 h and 3 months after administered gadolinium. Results In five patients, the gadolinium could appear in parts of the perilymph inside the inner ear but not in the middle ear and mastoid, moreover, the border between the perilymph and endolymph was visible so that endolymphatic space was clearly shown on 3D-FLAIR imaging. In two patients with endolymphatic hydrops, the perilymphatic space surrounding endolymph was small or disappeared. In two patients, the gadolinium could appear in parts of the middle ear and mastoid but not in the inner ear. No significant changes in pure tone test and tympanometry were noted. Conclusions 3D-FLAIR MRI with intratympanic gadolinium through eustachian tube could clearly reveal the visualization of endolymphatic space in Meniere＇s disease.
出处
《中华耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2010年第4期324-327,共4页
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
关键词
梅尼埃病
迷路液
磁共振成像
投药途径
Meniere disease
Labyrinthine fluids
Mgnetic resonance imaging
Drug administration routes
