摘要
以2-氯苯并噻唑为原料,在N,N-二异丙基乙基胺存在下与D或L-苯甘氨醇反应后,不经分离直接与甲磺酰氯在N,N-二异丙基乙基胺作用下关环,一锅法合成了(R)或(S)-2,3-二氢-2-苯基咪唑[2,1-b]苯并噻唑,利用IR、1HNMR、MS谱和旋光度对其结构进行了表征。通过优化研究2,3-二氢-2-苯基咪唑[2,1-b]苯并噻唑的合成工艺条件,可得到总收率为80%的(R)或(S)-2,3-二氢-2-苯基咪唑[2,1-b]苯并噻唑。
A one-pot synthesis of acyl transfer catalyst benzotetramisole was achieved by the reaction of 2-chlorobenzothiazole with D or L-phenylglycinol in the presence of N,N-diisopropyl ethylamine,followed by subsequent cyclization in the presence of methanesulfonyl chloride.The structures of the compounds were characterized by IR,^1HNMR,MS spectra and optical rotation analysis.The experimental results showed that the products were （R）-or （S）-2,3-dihydro-2-phenyl-imidazo[2,1-b]benzothiazole and their yields were 80% under the reaction conditions.
出处
《化学试剂》
CAS
CSCD
北大核心
2010年第4期293-295,298,共4页
Chemical Reagents
基金
国家自然科学基金资助项目(20602007)
