摘要
目的：高效液相色谱法测定不同制剂中利巴韦林的含量作一综述。方法：收集高效液相色谱法测定利巴韦林含量方法，分析总结。结果：高效液相色谱法测定制剂中利巴韦林的含量，固定相一般为C18柱，流动相一般为水或甲醇一水，流速一般为1．0ml·min^-1，检测波长为207nm，柱温为30℃或室温，进样为10或20μl。结论：高效液相色谱法测定制剂中利巴韦林的含量，具有良好的回收率和精密度，而且简便快捷，不受制剂中其他组分的干扰，是一种测定利巴韦林含量的可行方法。
Objective ： High performance liquid chromatography the content of different preparations of ribavirin are reviewed. Methods： HPLC determination of ribavirin concentration method, analyzed and summarized. Resuits ： The high - performance liquid chromatography preparation of ribavirin content of stationary phase is usually C la column, mobile phase is generally water or methanol - water, flow rate is generally 1.0 ml·min^-1 The detection wavelength was 207nm, column temperature of 30℃ or room temperature, injection of 10 or 20td. Conclusion ： The high - performance liquid chromatography preparation of the content of ribavirin, has a good recovery and precision, but also simple and quick, without the interference of agents of other components, is a determination of ribavirin content feasible.
