摘要
目的:探讨血管内皮生长因子VEGF和p53蛋白在宫颈癌及正常宫颈组织中的表达及意义。方法:采用免疫组化SP法检测VEGF和p53蛋白在55例宫颈癌、15对经放化疗前后的宫颈癌组织、18例正常宫颈组织中的表达情况。结果:VEGF和p53蛋白在宫颈癌中强阳性表达、正常宫颈组织中少量表达,两者之间有显著性差异(P<0.05);VEGF和p53的表达与宫颈癌临床分期显著相关(P<0.05),与分化程度显著相关(P<0.05),与放化疗前后相关(P<0.05);VEGF与p53蛋白在宫颈癌组织中阳性表达呈正相关(P<0.01)。结论:VEGF和p53蛋白在宫颈癌的演进中,尤其在宫颈癌的浸润和转移方面,很可能起着相互促进的作用。因此,联合检测VEGF和p53蛋白的表达可提高宫颈癌的转移及预测临床诊治的准确性。
Objective：To investigate the expressions and significances of between the vascular endothelial growth factor（VEGF） and p53 in human cervical carcinoma. Methods：The expression of VEGF and TGFβ1 were examined was examined in 55 specimens of human cervical carcinomas,10 patients with cervical cancer before and after radiotherapy and chemotherapyand 18 specimens of normal cervix as the control by sp immunohistochemistry staining. Results：The positive expression rate of VEGF and p53 in cervical carcinomas groups were significantly higher positive expression rates of VEGF and p53 than those in the control（P 0. 05,respectively） .With the cancerous focus size,clinical stage and pathological grade increasing and after radiotherapy and chemotherapythe,positive expression rates of VEGF and p53 were significantly high in cervical carcinomas（P0.05） . The expression of VEGF was positive related to p53 in cervical carcinomas（P0.01） . Conclusion：The expression levels of VEGF and p53 were related significantly to the invasive growth and metastasisofhumancervicalcarcinomas.Theyplayanimportantroleduringtheoccurrenceanddevelopmentofhumancervicalcarcinomas.
出处
《现代生物医学进展》
CAS
2010年第2期313-315,共3页
Progress in Modern Biomedicine
