摘要
目的探讨ＨＬＡＤＲＤＱ连锁基因单倍体与成人缓慢进展型１型糖尿病（ＳＰＩＤＤＭ）和速发型１型糖尿病（ＦＰＩＤＤＭ）的相关性。方法利用ＰＣＲ／ＳＳＰ技术检测了５２例ＳＰＩＤＤＭ患者、３０例ＦＰＩＤＤＭ患者和１３０例正常人的ＨＬＡＤＲＤＱ连锁基因频率。结果①ＨＬＡＤＱＡ１０３０１ＤＱＢ１０２０１和ＤＱＡ１０５０１ＤＱＢ１０２０１连锁基因单倍体与ＳＰＩＤＤＭ（Ｐｃ＜０．００１）和ＦＰＩＤＤＭ（Ｐｃ＜０．００１）均呈显著正相关；②ＨＬＡＤＱＡ１０３０１ＤＱＢ１０３０１和ＤＱＡ１０３０１ＤＱＢ１０６０２连锁基因单倍体与ＳＰＩＤＤＭ呈显著正相关（Ｐｃ＜０．００１）；③ＨＬＡＤＱＡ１０３０１ＤＱＢ１０３０２，ＤＱＡ１０３０１ＤＱＢ１０３０３及ＤＲＢ１０３０１ＤＱＡ１０３０１ＤＱＢ１０２０１连锁基因单倍体与ＦＰＩＤＤＭ呈显著正相关（前二者Ｐｃ＜０．０１，后者Ｐｃ＜０．００１）。结论ＳＰＩＤＤＭ和ＦＰＩＤＤＭ虽然均为自身免疫性糖尿病，但其ＨＬＡ表型并不完全相同，不同的ＨＬＡ表型可能是决定患者起病方式及病情发展不同的因素之一。
Objective To investigate the possible relationship of HLA DR DQ gene haplotype and Slowly Progressive IDDM (SPIDDM) and Fast Progressive IDDM (FPIDDM) in adults. Methods HLA DR DQ gene haplotypes in SPIDDM patients (n=52), FPIDDM patients (n=30) and healthy controls (n=130) were determined by PCR/SSP techniques. Results ①The frequencies of HLA DQA1*0301 DQB1*0201 and DQA1*0501 DQB1*0201genehaplotypesweresignificantlyhigher in both SPIDDM (Pc<0.001) and FPIDDM (Pc<0.001) patients; ②The frequencies of HLA DQA1*0301 DQB1*0301and DQA1*0301 DQB1*0602 gene haplotypes were significantly higher in SPIDDM patients (Pc<0.001). ③The frequencies of HLA DQA1*0301 DQB1*0302, DQA1*0301 DQB1*0303 and DRB1*0301 DQA1*0301 DQB1*0201 gene haplotypes were significantly higher in FPIDDM patients (Pc<0.01,Pc<0.01 and Pc<0.001 respcetively). Conclusion HLA DR DQ gene haplotype contributes the susceptibility to SPIDDM and FPIDDM. Compared with FPIDDM, the slowly progressive course of SPIDDM may be related to different susceptibility genes.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1998年第5期302-304,共3页
Chinese Journal of Endocrinology and Metabolism
