摘要
目的：探讨蛋白酶ＩＣＨ－１与鼻咽癌发生的关系。方法：应用免疫组化ＳＰ法研究４６例鼻咽癌组织中ＩＣＨ－１和增殖细胞核抗原（ＰＣＮＡ）的表达。结果：４６例鼻咽癌中１６例ＩＣＨ－１Ｌ阳性，２２例ＩＣＨ－１Ｓ阳性，阳性率分别为３４８％和４７８％，ＩＣＨ－１Ｌ阳性细胞百分率为５４２％，ＩＣＨ－１Ｓ阳性细胞百分率为６８４％，较良性鼻咽上皮增加。４６例鼻咽癌细胞ＰＣＮＡ增殖指数为４９８±７２％，较良性鼻咽上皮增加，ＰＣＮＡ表达与癌细胞分化有关。结论：蛋白酶ＩＣＨ－１异常表达可能与鼻咽上皮癌变有关。ＰＣＮＡ可作为反映鼻咽癌细胞分化的一项指标。
Objective:To study the relationship between proteinase ICH 1 and tumorigenesis of nasopharyngeal epithelium.Methods:Immunohistochemistry technique was employed to detect the expression of ICH 1 (including ICH 1S and ICH 1L) and proliferating cell nuclear antigen (PCNA) in 46 cases of nasopharyngeal carcinoma (NPC). Results :16 cases were positive for ICH 1L (positive rate 34.8%)and 22 cases were positive for ICH 1L (positive rate 47.8%). The percentage of positive cells for ICH 1L and ICH 1S was 54.2% and 68.4%, respectively. The ratio of ICH 1L to ICH 1S (positive rate and percentage of positive cells)changed in benign lesions and NPC. PCNA index was 49.8%±7.2% in NPC. PCNA expression was related to cell differentiation. Conclusion: ICH 1 may be involved in carcinoigenesis of nasopharyngeal epithelium.PCNA may serve as a marker for the evaluation of cell differentiation of NPC.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
1998年第4期222-225,共4页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
