摘要
目的探讨乌苞酿对小鼠免疫功能的影响和急性毒性。方法采用免疫器官重量法、腹腔巨噬细胞功能测定法,测定乌苞酿对正常小鼠和环磷酰胺所致免疫抑制小鼠的免疫调节作用;并测定乌苞酿小鼠灌服给药的急性毒性。结果乌苞酿可显著提高正常小鼠和免疫低下小鼠胸腺重量指数(P<0.05);显著提高免疫低下小鼠巨噬细胞对鸡血红细胞吞噬百分率和吞噬指数(P<0.05)。小鼠灌服乌苞酿的急性毒性实验未观察到明显毒性反应,最大耐受量为12.2g生药/kg体重。结论乌苞酿具有良好的免疫增强作用,具有良好的安全性。
Objective To study the effect of Wubaoniang on immunological function and acute toxicity in mice.Methods The methods of the weight of mice＇s immune organs,peritoneal macrophage phagocytic capacity were taken to assess the effect of Wubaoniang on immunological function of normal mice and mice with immunosuppression caused by cyclophosphamide,and the acute toxicity was detected by intragastric administration Results Wubaoniang could significantly increased the weight index of thymus on normal and immunity deficiency of mice（P〈0.05）,increase erythrocytes of chicken phagoctic percentage and phagocytic index of phagocyt immunity deficiency of mice（P〈0.05）,obvious toxic reaction was not observed and the maximum tolerant dose was 12.2 g/kg for mice in acute toxicity experiment.Conclusion Wubaoniang could enhance the immunological function and is favorable safe.
出处
《广西医学》
CAS
2010年第1期12-15,共4页
Guangxi Medical Journal
基金
广西医疗卫生科学研究基金(桂卫科重200943)
关键词
乌苞酿
免疫调节
急性毒性
小鼠
Wubaoniang Immunological regulation Acute toxicity Mice
