摘要
目的:以补肾祛痰化瘀立法组方(补元聪脑汤)治疗阿尔茨海默病(Alzheimer disease,AD)模型大鼠,并观察其海马区胆碱乙酰转移酶(ChAT)和乙酰胆碱酯酶(AchE)活性变化。方法:在大鼠海马区内注入鹅膏蕈氨酸(IBO)和β样淀粉蛋白1-42肽段(Aβ1-42)混合液造成AD模型,以补元聪脑汤和西药脑复康混悬液分别灌胃治疗。通过比色法测定大鼠海马内ChAT和AchE活性。结果:补元聪脑汤能增加AD大鼠海马内的ChAT和AChE活性。结论:补元聪脑汤对AD模型大鼠海马区ChAT和AChE活性变化有明显改善。
Objective： To observe the effects of the Alzheimer＇s disease （AD） model rats of the hippocampus cholinergic system＇s ChAT and AchE activity through replenishing kidney- essence and removing Phlegm therapy and blood（Buyuan congnao decoction）. Methods： replenishing kidney- essence and removing Phlegm therapy and blood and Nao fukang will be given to the treatment of the AD model rats were established by injecting A β 1-42 ＋IBO into districts of hippocampal; the impact on cholinergie system in rats will be tested. Restdts： there was an increase in the AD hippocampal ChAT and AChE activity. Conclusion： AD model rats on hippocampus ChAT and AChE activity in a significant improvement through Buyuan congnao decoction.
出处
《辽宁中医药大学学报》
CAS
2010年第4期88-89,共2页
Journal of Liaoning University of Traditional Chinese Medicine
基金
辽宁省教育厅课题(20060551)
关键词
补肾祛痰化瘀
阿尔茨海默病
大鼠
CHAT
ACHE
replenishing kidney- essence and removing phlegm therapy and blood
Alzheimer＇s disease
rat
ChAT
Ache
