摘要
目的:观察川芎嗪与肝素合用对52例肺心病急性期血液流变学的影响。方法:52例病人在综合治疗的基础上用川芎嗪注射液480mg加入5%葡萄糖或葡萄糖氯化钠注射液500ml中,每日1次;普通肝素6250U,每日2次,皮下注射,7d为1疗程,治疗前后做血液流变学检测。结果:应用川芎嗪和肝素后病人血液粘度、红细胞压积、纤维蛋白元、红细胞变形系数、血栓形成系数等较治疗前有明显降低(P<0.01)。结论:提示肺心病人在急性发作期血液存在"浓、粘、聚、凝"的病理过程,川芎嗪和肝素合用可降低血粘度,改善微循环,缓解支气管痉挛及降低痰液粘稠性,有利于病情缓解。
Objective：To observe the blood rheology changes of 52 patients with pulmonary heart disease in acute phase after treated by tetramethylpyrazine and heparin.Methods：On the basis of the combined treatment,52 patients were treated with 500 ml 5% glucose or glucose and sodium chloride injection with 480 mg tetramethylpyrazine injection,once a day;unfractionated heparin 6250U,2 times a day for subcutaneous injection,7d for a course of treatment,blood rheology testing was done before and after treatment.Results：Blood viscosity,hematocrit,fibrinogen,erythrocyte deformation coefficient,and thrombosis significantly decreased after treated with tetramethylpyrazine and heparin（P0.01）.Conclusion：The pathological process of thickness,stickiness,gathering and coagulation of the blood exists in the acute period of onset of pulmonary heart disease.The combination of tetramethylpyrazine and heparin can reduce blood viscosity,improve microcirculation and ease bronchial spasm,reduce sputum viscosity and improve the state of illness.
出处
《中医学报》
CAS
2010年第2期276-276,278,共2页
Acta Chinese Medicine
关键词
肺原性心脏病
血液流变学
川芎嗪
肝素
pulmonary heart disease
blood rheology
tetramethylpyrazine
heparin
