摘要
目的研究儿童注意缺陷多动障碍（ADHD）与非ADHD儿童体内脂肪酸水平差异及膳食补充n-3类脂肪酸对ADHD儿童体内脂肪酸水平的影响作用。方法在1 555名2-5年级学生中筛选出ADHD儿童79名,取50名非ADHD儿童作为对照,采集静脉血分析其脂肪酸差异。采用随机对照试验（RCT）原则,将ADHD儿童随机分为干预组和对照组,采用不同浓度的n-3多不饱和脂肪酸（PUFAs）膳食补充干预3个月,观察干预后脂代谢改善情况。结果ADHD儿童血红细胞膜的饱和脂肪酸（SFAs）中的C15∶0、C16∶0、C20∶0,单不饱和脂肪酸（MUFAs）中的C15∶1、C18∶1、C20∶1、C24∶1及PUFAs中的亚油酸C18∶2 n-6（LA）明显高于非ADHD组儿童（P〈0.05）;花生四烯酸C20∶4 n-6（AA）、二十碳五烯酸C20∶5 n-3（EPA）及C22∶4（n-6）低于非ADHD组儿童。ADHD儿童补充n-3PUFAs后,体内α-亚麻酸C18∶3 n-3（ALA）、C24∶0、二十二碳六烯酸C22∶6 n-3（DHA）及n-3PUFAs水平显著提高,n-6PUFAs、n-6/n-3比例则显著降低。结论ADHD与非ADHD儿童体内的脂肪酸组成存在差异,补充n-3类脂肪酸可提高ADHD儿童体内n-3类脂肪酸水平,同时降低n-6/n-3比例。
Objective To investigate the difference of fatty acids（FA）composition of red blood cell（RBC） membrane between children with attention deficit hyperactivity disorder（ADHD） and those without the problem,and to evaluate the effect of dietary supplement of n-3 polyunsaturated fatty acids（PUFAs） on FA profile of RBC membrane in children with ADHD.Methods A total of 1 555 primary school students,aged 7-12 years,were recruited,in which 79 children were diagnosed as ADHD;50 children without ADHD were selected as control group.FA composition was analyzed by capillary gas chromatography.A design of randomized controlled intervention was used for the study.The students with ADHD were divided into intervention group or control,which were treated with n-3 PUFAs rich eggs or ordinary eggs for 3 months respectively.The FA composition of RBC membrane was analyzed for children of pre-and post-intervention.Results The ADHD group had higher concentration of saturated fatty acids（SFAs）：C15∶0,C16∶0,C20∶0;of monounsaturated fatty acids（MUFAs）：C15∶1,C18∶1,C20∶1,C24∶1;and of linolenic acid（LA）than those in control group.The concentration of arachidonic acid（AA）,eicosapentaenoic acid（EPA） and C22∶4（n-6） were significantly lower in the ADHD group than those in control group.The intervention of n-3 PUFAs supplement increased concentration of C24∶0,α-linolenic acid（ALA）,docosahexaenoic acid（DHA） and n-3 PUFAs.The concentration of n-6 PUFAs and ratio of n-6/n-3 were decreased after intervention.Conclusion There were significant differences in PUFAs and n-3 PUFAs concentrations between children with and without ADHD.Supplementation of n-3 PUFAs would increase DHA and n-3 PUFAs and decrease n-6/n-3 ratio in children with ADHD.
出处
《中国预防医学杂志》
CAS
2010年第3期257-260,共4页
Chinese Preventive Medicine
关键词
儿童注意缺陷多动障碍
长链多不饱和脂肪酸
n-3类脂肪酸
Attention deficit hyperactivity disorder（ADHD）
Long-chain polyunsaturated fatty acids
N-3 fatty acids
