摘要
目的：了解某院结核病人2000-2007年常用10种抗结核药物的耐药性。方法：根据WHO耐药指南要求,使用WHO推荐的比例法进行药敏试验,某院2000年至2007年的涂阳病例为本次研究对象。并对全部培养阳性的菌株用比例法做INH、SM、RFP、EMB、TH1321、PAS、AMK、KM、OFLX、CPM 10种药物的药敏试验。结果：共入选涂阳病人1250例,其中培养阳性1136例,培养阴性108例,污染6例,耐药菌株858例,总耐药率56.8%,初始耐药率为56.6%,获得性耐药率为67.5%,耐多药率为4.5％；同时对不同年份MDR（耐多药）及XDR（广泛耐药）的分布情况进行了统计。结论：结核分枝杆菌对多种药物的耐药性相差异。耐药性流行为初复治耐药率呈逐年上升趋势。结核分枝杆菌耐药性流行水平有上升趋势，建立WHO／IUATLD结核病耐药监测系统，获得了耐药性水平资料，对临床用药具有重要的指导意义。
Objective：To collect the data of drug resistance based the established surseillance system for antituberculosis drug resistance according to WHO/IUATLD guidelines to evaluate the prevalence trend of 10 antituberculosis drugs commonly.Methods：The study objectives were smear positive pulmonary tuberculosis cases of HeNan Chest Hospital from 2000 to 2007.susceptibility tests（proportion method for INH,SM,RFP,EMB,TH1321,PAS,AN,KM,OFLX and CPM）were done in all culture positive specimens.Results：1250 patients with pulmonary tuberculosis cases involved in the study.Among of them,1136 were culture positive,the total drug resistance rate was 56.8%.the rate of the tuberculosis multi-drugs resistance is very different.The drug resistance trend was rising yearly.Conclusion：The anti-tuberculosis drug resistant surveillance and quality control system are established.The reliable data on the status of anti-tuberculosis drug resistance results provide the evidences for improvement and assessment on TB control measures and clinical drug use.
出处
《中国卫生检验杂志》
CAS
2010年第2期338-340,共3页
Chinese Journal of Health Laboratory Technology
关键词
结核
分枝杆菌
耐药
监测
Tuberculosis
Mycobacterium tuberculosis
Drug resistant
Surveillance
