摘要
目的分析泰安市结核病防治院痰培养阳性肺结核就诊患者的耐药状况。方法就2011年1月至12月在泰安市结核病防治院就诊的233例痰培养阳性肺结核患者对S、Km、INH、RFP、EMB和PAS等6种抗结核药物的药敏情况及耐药类型进行分析。初治组患者171例,复治组患者62例,结果比较采用χ2检验,P<0.05为差异有统计学意义。结果233例痰培养阳性肺结核患者的耐药率为52.36%(122/233),其中初治痰培养阳性患者耐药率为51.46%(88/171);复治痰培养阳性患者耐药率为54.84%(34/62)。痰培养阳性肺结核患者对一线抗结核药物耐药率较高,INH耐药率最高(30.04%,70/233),其次是S(24.46%,57/233)、EMB(23.18%,54/233)和RFP(16.74%,39/233)。耐药类型中,主要是多耐药结核病(50.00%,61/122),其次是单耐药结核病(28.69%,35/122)和MDR-TB(21.31%,26/122)。233例患者的MDR-TB耐药率为11.16%(26/233),复治患者中MDR-TB的耐药率(19.35%,12/62)高于初治组(8.19%,14/171),差异有统计学意义(χ2=5.724,P<0.05);用过抗结核药的初治患者中MDR-TB的耐药率(23.08%,6/26)高于未用抗结核药的初治患者(5.52%,8/145),差异有统计学意义(χ2=6.699,P<0.05)。结论泰安市结核病防治院就诊的痰培养阳性的肺结核患者总体耐药率及INH、S、EMB和RFP的耐药率较高;复治患者和曾用过抗结核药的初治患者更容易发生MDR-TB。
Objective To analyze the Mycobacterdum tuberculosis drug-resistance situation of sputum cuhur, positive patients visiting Tai＇an TB Prevention and Treatment Hospital. Methods From January 2011 to Decem ber 2011, a total of 233 sputum culture positive patients visited Tai＇an TB Prevention and Treatment Hospital, weanalyzed their drug susceptibility situation for 6 kinds of anti-TB drugs, namely S, Km, INH, RFP, EMB and PAS and their resistance pattern. According to the treatment history, patients were divided into new patients grout （171 cases） and retreatment group （62 cases）. Chisquare test was used to analyze if the difference is statistically significant （P〈0.05）. Results The overall drugresistant rate of 233 sputum culture patients was 52.36%, （122/233）, with 51.46%（88/171） in new patients and 54.84G （34/62） in retreatment patients. Sputum cultur, positive patients had high drug susceptibility rate to first line drugs, with the highest of INH （30.04G, 70/233/ followed by S （24.46G ,57/233）, EMB （23.18% ,54/2331 and RFP（16.74% ,39/233）. In terms of resistance pat tern, the majority was multidrug resistant TB （50.00% 61/122）, followed by singledrug resistant TB （28.69% 35/122/ and multi drug resistant （MDR） TB （21.31%, 26/122）. The overall MDRTB rate was 11.16%（26/233）, with 19.35G（12/62） in new patients and 8.19%（14/171） in new patients, the difference between two, groups is statistically significant（χ2= 5. 724, P〈C0.05）. The MDR-TB rate （23.08 %, 6/26 ） in patients ever usec anti-TB drugs was higher than those never taken anti TB drugs before （5.52G ,8/145）, and the difference is statis tically significant（χ2=6. 699,P〈0.05）. Conclusion The overall drugresistance rate of Mycobacterium tuberculosi and INH, S, EMB, RFP drugresistance rates are high in sputum culturepositive patients visiting Tai’an TB Pre vention and Treatment Hospital, and the retreatment and new patients who had taken anti-TB drugs before are mor likely to develop MDR TB.
出处
《中国防痨杂志》
CAS
2012年第11期736-739,共4页
Chinese Journal of Antituberculosis
基金
泰安市科技发展计划(20113091)
关键词
结核
肺
分枝杆菌
抗药性
细菌
泰安市
Tuberculosis, pulmonary
Mycobacterium
Drug resistance, bacterial
Taian city
