摘要
【目的】观察α-硫辛酸治疗糖尿病周围神经病变的临床效果及对胰岛素样生长因子-Ⅰ的影响。【方法】32例糖尿病周围神经病变患者均在积极控制糖尿病的基础上,采用α-硫辛酸剂量为600mg/d,静脉滴注,连用14d为1个疗程;比较治疗前后神经传导速度的变化和神经病变症状评估。【结果】经α-硫辛酸治疗后,MNCV,SNCV及TSS评分均明显改善;可明显改善糖尿病周围神经病变患者的刺痛、烧灼感、和感觉异常,对麻木改善不明显。使糖尿病周围神经病变患者治疗前后IGF-Ⅰ的表达上调,有显著性差异。【结论】α-硫辛酸可以改善糖尿病周围神经病变患者的神经传导速度,改善患者的自觉症状可能与上调IGF-Ⅰ水平有关。
[Objective]To observe the α-lipoic acid on nerve conduction velocity and in with insulin-like growth factor in diabetic peripheral neuropathy patients.[Methods] A total of Will be 32 cases of diabetic peripheral neuropathy patients with active control of diabetes were given α-lipoic acid（600mg/d）,intravenous drip for 14d a course.Nerve conduction velocity changes and neuropathy assessment of the symptoms were before and after treatment compared [Results] After α-lipoic acid treatment,MNCV,SNCV and TSS score were significantly improved.Expression of IGF-Ⅰ up-regu lated.[Conclusions] α-lipoic acid can improve the nerve conduction velocity in diabetic peripheral neuropathy patients,and the patient＇s symptoms improvement may be related to the increased levels of IGF-Ⅰ.
出处
《武警医学院学报》
CAS
2010年第3期191-192,195,共3页
Acta Academiae Medicinae CPAPF
