摘要
【目的】研究缬沙坦与螺内酯联合应用能否增加心衰患者左室功能、搏出量和容积。【方法】48例慢性心力衰竭患者,随机分成对照组(25例)与试验组(23例),分别接受1年缬沙坦联合安慰剂治疗和缬沙坦联合螺内酯治疗。治疗1年后,通过超声心动图的组织多普勒成像(TDI)来评价其心肌重塑情况,检测指标包括收缩速度峰值、基础收缩紧张度、集中反向散射周期变异。【结果】经过1年的随访,试验组左室射血分数(LVEF)明显增高(P<0.05),左室舒张末期容积指数(LVEDVI)减少(P<0.05),左室收缩末期容积指数(LVESVI)减少(P<0.05),左室质量指数(LVMI)减低(P<0.05)。试验组TDI测定收缩速度峰值(Sm),基础收缩紧张度,集中反向散射周期变异(CVIB)增加,充盈压明显减少(P<0.05)。【结论】缬沙坦联合螺内酯对慢性心力衰竭患者逆转心肌重塑效果明显。
[Objective]To determine the feasibility of valsartan and spironolactone in improving left ventricular（LV）function,mass,and volumes in chronic heart failure patients.[Methods] Forty-eight patients with chronic heart failure were randomly assigned to receive 1 year treatment of valsartan and spironolactone（combination group 25 patients）or valsartan and placebo（control group 23 patiens）.Reverse remodeling was assessed by echocardiographic tissue Doppler imaging（TDI）.[Results] There were significant improvements in LVEF（P0.05）and reduction of LV end-diastolic volume index（P0.05）,end-systolic volume index（P0.05）and LV mass index（P0.05）in the combination group at the end of 1 year.And there was significant increase in peak systolic velocity and systolic strain by TDI,increase in cyclic variation of integrated backscatter and decrease in index of filling pressure.[Conclusions] The addition of spironolactone to valsartan has significant beneficial effects on the reversing of myocardial remodeling in patients of with chronic heart failure.
出处
《武警医学院学报》
CAS
2010年第3期178-180,共3页
Acta Academiae Medicinae CPAPF
关键词
缬沙坦
螺内酯
慢性心力衰竭
心肌重塑
Valsartan
Spironolactone
Chronic heart failure
Myocardial remodeling
