摘要
目的探讨心型脂肪酸结合蛋白和同型半胱氨酸联合检测在慢性心力衰竭诊断中的应用价值,并结合相关临床表现,为临床诊治提供依据。方法选择2013年2月至2014年4月确诊为慢性心力衰竭的患者68例作为试验组,同期健康体检人员70例作为对照组,并对心型脂肪酸结合蛋白、同型半胱氨酸水平进行检测。结果与对照组比较,试验组患者的心型脂肪酸结合蛋白和同型半胱氨酸水平均有明显升高,差异有统计学意义(P<0.05);试验组单独检测心型脂肪酸结合蛋白和同型半胱氨酸的阳性率分别为86.76%、88.24%,均低于联合检测阳性率(94.12%),差异有统计学意义(P<0.05);以临床诊断为金标准,2项指标联合检测结果与临床诊断结果 Kappa一致性分析得出Kappa=0.94。结论心型脂肪酸结合蛋白和同型半胱氨酸对于慢性心力衰竭疾病的辅助诊断具有一定的临床价值,两者联合检测能有效提高阳性检出率,降低漏诊率。
Objective To explore the clinical significance of the heart-type fatty acid-binding protein and homocysteine combined testing to the chronic heart failure diagnosis Methods 68 cases of patients of chronic heart failure were chosed as the study group and 70 cases healthy were checked up as the control group.The levels of hearttype fatty acid-binding protein and homocysteine testing were analyzed.Results Compared with the control group,the levels of heart-type fatty acid-binding protein and homocysteine in the study group were significantly higher than those of the control group（P〈0.05）.The positive detection rate of the heart-type fatty acid-binding protein and homocysteine in the study group was 86.76% and 88.24%,and the positive detection rate of the two indicators combined testing was 94.12%,which was significantly higher than those of separate testing.Compared with the gold standard of clinical diagnosis,the Kappa was 0.94.Conclusion There is a certain clinical value of the heart-type fatty acid-binding protein and homocysteine to the chronic heart failure diagnosis,and we can effectively improve the positive rate by combined testing,reduce the rate of misdiagnosis.
出处
《检验医学与临床》
CAS
2015年第8期1097-1098,共2页
Laboratory Medicine and Clinic
