摘要
目的:观察天山雪莲提取物大孔树脂纯化前后各个部位抗炎镇痛作用。方法:用二甲苯致小鼠耳廓肿胀和冰醋酸致小鼠腹腔毛细血管通透性的影响观察抗炎作用;采用醋酸扭体法和热板致痛法观察镇痛作用。结果:30%～50%乙醇洗脱部位可明显抑制二甲苯所致小鼠耳廓的肿胀度和冰醋酸致小鼠腹腔毛细血管通透性增高;对抗醋酸所致小鼠的扭体次数增加,提高热板所致小鼠的痛阈值。结论:30%～50%乙醇洗脱部位具有明显的抗炎、镇痛作用。
OBJECTIVE To observe the anti-inflammatory and analgesic effects of various parts from saussurea involucrate purified by macroporous resin in mice. METHODS The models of mouse ear tumefaction caused by xylene and abdominal capillary permeability caused by glacial acetic acid were used to observe the anti-inflammatory effect of various parts from saussurea involucrate. The models of mouse body writhing caused by acetic acid and pain caused by hot plate were used to observe the an algesics effect of various parts. RESULTS The part eluted with 30%-50% alcohol could restrain mouse ear tumefaction and andominal capillary permeability, reduce mouse body-writhing number in acetic acid model and elevate the pain threshold with hot plate method. CONCLUSION The results showed that the part eluted with 30%-50% alcohol possesses the anti-inflammatory and analgesic effects.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2010年第5期374-377,共4页
Chinese Journal of Hospital Pharmacy
基金
新疆维吾尔自治区科技攻关重大专项(编号:200733146-4)
宿州学院硕士科研启动基金(编号:2009YSS10)
关键词
天山雪莲
大孔树脂
30%~50%乙醇洗脱部位
抗炎
镇痛
saussurea involucrate
macroporous resin
30%-50% alcohol elution
anti-inflammatory
analgesia
