摘要
目的:优化克疣纳米乳的处方工艺。方法:以外观性状和粒径的综合评分为因变量,混合表面活性剂-肉豆蔻酸异丙酯(IPM),聚山梨酯80-无水乙醇、水-表面活性剂为自变量,采用星点设计-效应面优化法优选克疣纳米乳的处方工艺。结果:最佳处方为混合表面活性剂-IPM(8.090∶1),聚山梨酯80-无水乙醇(3.082∶1),水-表面活性剂(8.606 1∶1)。制备的克疣纳米乳平均粒径27.46 nm,Zeta电位-0.522 4 mV。结论:优化的处方工艺稳定可行,制备的克疣纳米乳质量符合要求。
Objective： To optimize prescription of Keyou nanoemulsion.Method： With composite score of appearance and particle size as dependent variable,ratio of mixed surfactant-isopropyl（IPM）,tween 80ethanol and water-surfactant as independent variables,blank prescription of Keyou nanoemulsion was optimized by central composite design-response surface methodology,and then added drug to prepared blank Keyou nanoemulsion.Result： Optimal prescription was as following： mixed surfactant-IPM（8.090 ∶ 1）,tween 80ethanol（3.082∶ 1）,water-surfactant（8.606 1 ∶ 1）.Average particle size of prepared Keyou nanoemulsion was 27.46 nm,Zeta potential value was-0.522 4 mV.Conclusion： This optimized process was stable and feasible for preparation of Keyou nanoemulsion.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第14期39-42,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
郑州市科技攻关项目(0910 SGYS33390-2)
关键词
克疣纳米乳
星点设计效应面法
粒径
Keyou nanoemulsion
central composite design response surface methodology
particle size
