摘要
本研究的目的是研究抑郁症患者与健康人静息态脑功能的差别。对符合DSM-IV诊断标准的53例抑郁症患者和38例正常对照进行静息态功能磁共振扫描,采用局部一致性(regional homogeneity,ReHo)的方法分析数据,然后进行基于体素的组间比较,分析其静息态脑功能的差异。结果显示与正常组相比,抑郁组在双侧前扣带皮质(anterior cingulate cortex,ACC)、左侧内侧前额叶皮质、左侧颞中回均有ReHo值降低。ACC位置ReHo值显著降低提示抑郁症患者在前扣带皮质及其相邻部位自发神经活动异常。
This study sought to reveal the difference in resting-state brain functions between subjects with major depressive disorder and normal controls.Fiftythree depressed patients diagnosed with DSM-IV and 38 normal controls underwent resting-state functional magnetic resonance imaging（fMRI）,and the data were analyzed using a new method called Regional Homogeneity（ReHo）.Then voxel wised comparison was made to derive the resting-state brain function differences between groups.Compared with normal controls,depressed subjects showed decreased ReHo in bilateral anterior cingulate cortex（ACC）,left medial frontal gyrus,and left middle temporal gyrus.Significant decreased ReHo in ACC might suggest less spontaneous neuronal activities or lower baseline brain activities of ACC in depressed subjects in comparison with normal controls.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2010年第1期16-19,共4页
Journal of Biomedical Engineering
基金
"十五"国家科技攻关资助项目(2004BA720A21-01)
高等学校博士学科点专项科研基金资助项目(20060610073)
新教师基金资助项目(20070610153)
关键词
抑郁症
功能磁共振
静息态
前扣带皮质
Depressive disorder
Functional magnetic resonance imaging（fMRI）
Resting-state
Anterior cingulate cortex（ACC）
