摘要
目的:探讨静息态下抑郁症患者脑局部一致性(regional homogeneity,ReHo)与抑郁症状群的关联。方法:17名首发重性抑郁症患者与17名性别、年龄、教育程度相匹配的健康者参与了静息态功能磁共振(fMRI)的扫描。将患者的脑ReHo值与其抑郁症状群进行相关分析,设P<0.005,k值≥10为相关具有统计学意义。结果:抑郁症患者以下症状群与脑区的相关具有统计学意义。焦虑与右前额中部、左脑岛ReHo值呈负相关(r=-0.85,-0.55;均P<0.001);认知障碍与左前额中部、右脑岛ReHo值负相关(r=-0.83,-0.67;P<0.01),而与右海马旁回ReHo值正相关(r=0.90;P<0.01);迟缓与左前额中部、右额下回、右尾状核ReHo值负相关(r=-0.66,-0.67,-0.55;均P<0.001),而与右前扣带回腹侧ReHo值呈正相关(r=0.80,P<0.001);睡眠障碍与左楔前叶、右脑岛ReHo值负相关(r=-0.72,-0.66;P<0.01);绝望感与左后扣带回ReHo值负相关(r=-0.84,P<0.001)。结论:本研究提示抑郁症患者的焦虑、认知障碍、迟缓、睡眠障碍及绝望感症状可能是部分特定的脑神经异常活动的表现。
Objective： To examine the relationship between regional homogeneity （ReHo） and separate symptom clusters of depression. Methods： Seventeen first-episode major depressed patients and 17 gender, age, and education matched normal controls experienced resting-state fMRI scans. Correlation analysis was performed in the ReHo value of depressed patients and symptom clusters, P 〈0. 005 and k value≥10 were used to determine the significance. Results： In depressed patients, anxiety was negatively correlated with the ReHo in right middle prefrontal cortex and left insula （ r = - 0. 85, - 0. 55 ; Ps 〈 0. 01 ） . Cognitive disturbance was negatively correlated with the ReHo in left middle prefrontal cortex and right insula （ r = - 0. 83, - 0. 67, Ps 〈 0. 01 ）, and positively correlated with the ReHo in right parahippocampal gyrus （ r =0. 90, P 〈0. 01 ） . Retardation was negatively correlated with the ReHo in left middle prefrontal cortex, right inferior frontal gyrus and right caudate （ r = - 0.66, - 0. 67 and - 0.55, Ps 〈 0. 01 ）, and positively correlated with the ReHo in right ventral anterior cingulate （ r = 0. 80, P 〈0. 01 ） . Sleep disturbance was negatively correlated with the ReHo in left precuneus and right insula （ r = - 0. 72, - 0. 66 ; Ps 〈 0. 01 ） . Hopelessness was negatively correlated with the ReHo in right posterior cingulate （r = -0. 84, P 〈 0. 01） . Confusion： The findings indicate that separate depressive symptom clusters such as anxiety, cognitive disturbance, retardation, sleep disturbance and hopelessness are associated with specific brain activity patterns.
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2009年第9期680-684,共5页
Chinese Mental Health Journal
基金
国家高技术研究发展计划(863计划)(2008AA02Z410)
国家自然科学基金(30500179)
江苏省自然科学基金(BK2005427)
南京市医学重点科技发展项目(ZKX05003)
儿童发展与学习科学教育部重点实验室开放课题(CDLS-2009-07)
关键词
抑郁症
磁共振成像
汉密尔顿抑郁量表
静息态
局部一致性
病例对照研究
depressive disorder
magnetic resonance imaging
hamilton rating scale for depression
resting state
regional homogeneity
case-control study
