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载脂蛋白E在蛛网膜下腔出血发病机制的研究

The Effect of Apolipoprotein E in Subarachnoid Hemorrhage
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摘要 目的:研究血清载脂蛋白E(ApoE)、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)与蛛网膜下腔出血(SAH)严重程度和预后的关系。方法:选取我院2005年-2008年诊断为SAH住院患者47例为实验组,同时选取年龄性别相匹配的健康体检者47例为对照组,两组均测定空腹肘静脉血清ApoE、TC、TG、HDL-C、LDL-C。结果:SAH患者血清ApoE水平随着病情的加重而增加,但与正常对照组相比差异无显著性;与预后良好组比较,预后不良组血清LDL、TC水平明显上升,具有显著性差异。结论:血清ApoE对SAH发病无明显影响;SAH患者的LDL、TC水平升高,与病情严重程度显著相关。 Objective: To observe subarachnoid hemorrhage(SAH) patients with serum apolipoprotein E(ApoE), total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C). Methods: We measured their serum ApoE, TC, TG, HDL-C, LDL-C in 47 patients with subarachnoid hemor- rhage who identified in Affiliated Hospital of Luzhou Medical College during 2005--2008 and 47 heahhy persons who identified in our hospital as controls. Results:There was no significant difference with ApoE between SAH patients and controls. The level of serum ApoE is related to the degree of patients with SAH. Serum TC and LDL were higher in patients with unfavorable results than in those with favorable on,s. Conclusion.. There was no relationship with ApoE on SAH,LDL and TC were related to the degree of SAH.
出处 《医学理论与实践》 2010年第3期252-253,共2页 The Journal of Medical Theory and Practice
关键词 载脂蛋白E 蛛网膜下腔出血 Apolipoprotein E, Subarachnoid hemorrhage
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