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对氧磷酶2C311S与对氧磷酶1Q192R基因多态性与糖尿病肾病的关系 被引量：3

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摘要 糖尿病（DM）并发肾病，进而发展为肾衰竭，是南多种因素综合作用所致，其中氧化应激和脂质代谢紊乱起着重要作用。对氧磷酶（PON）多基因家族成员PON1、PON2和PON3均具有抗动脉粥样硬化的作用。
作者 钱书虹 钱庆文
机构地区 郑州大学第一附属医院检验科
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2010年第2期132-133,共2页 Chinese Journal of Nephrology
关键词 糖尿病肾病 对氧磷酶 基因多态性 抗动脉粥样硬化 脂质代谢紊乱 氧化应激 PON1 家族成员
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献7

二级参考文献16

  • 1钱庆文,钱书晓,王诗瑾.糖尿病合并冠心病与芳香酯酶基因Q192R多态性分析[J].中国临床医学,2004,11(5):903-905. 被引量：2
  • 2赵伟佳,杨和平,沈岳飞,苏承华,林发全,黄春霞,阮立培.对氧磷酶2基因C311S多态性与脑梗死的相关性研究[J].中国老年学杂志,2005,25(2):117-119. 被引量：9
  • 3Calle R, McCarthy MI, Banerjee P, et al. Paraoxonase(PON2) polymorphisms and development of renal dysfunction in type 2 diabetes : UKPDS76[J]. Diabetologia, 2006,49(12):2892-2899.
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  • 8Ng CJ ,Wadleigh DJ, Gangopadhyay A, et al. Paraoxonase 2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein [ J ]. J Bio Chem, 2(}(}1,276 ( 30 ):44444- 44449.
  • 9Matinelli M, Girelli D, Olivieri O, et al. Interaction between smoking and PON2 Ser311Cys polmorphism as a determinant of the risk of myocardial infaretion[J]. Eur J Clin Invest,2004,34 (1):14-20.
  • 10FRISHBERG Y, TOLEDANO H, BECKER-COHEN R, et al.Genetic polymorphism in paraoxonase is a risk factor for childhood focal segmental glomerulosclerosis[J]. Am J Kidney Dis, 2000,36(6) :1253-1261.

共引文献3

同被引文献21

  • 1SUShao-yong,CHENJian-hong,HUANGJian-feng,WANGXiao-ling,ZHAOJian-gong,SHENYan,QIANGBo-qin,GUDong-feng.Paraoxonase gene cluster variations associated with coronary heart disease in Chinese Han women[J].Chinese Medical Journal,2005(14):1167-1174. 被引量：15
  • 2Wen-Chin Lee, I-Iong-Chen Chen, Chih-Ying Wang, et al. Ciloatazol ameliorates nephropathy in type 1 diabetic rats involving improvement in oxidative stress and regulation of TGF-β and NF-κB [ J ]. Bioscience, Biotechnology, and Biochemistry, 2010, 74 ( 7 ) : 1355- 1361.
  • 3Somani R,Singhai AK, Shivgunde P, et al. Asparagus race-mosus Willd (Lliaceae)ameliorates early diabetic nephropathy in STZ induced diabetic rats [ J ]. Indian Journal of Experimental Biology, 2012,50(7) :469-475.
  • 4Datta SK,Kumar V,Ahmed RS,et al. Effect of GSTM1 and GSTI3 double deletions in the development of oxidative stress in diabetic nephropathy patients[ J ]. Indian J Biochem Biophys,2010,47 (2) : 100-103.
  • 5Bock F,Shahzad K,Wang H,et al. Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66-(Shc ) [ J ]. Proceedings of the National Academy of Sciences of the United States of America,2013,110(2) :648-653.
  • 6Kimn G,Nandini CD,Ramesh HP,et al. Progression of early phase diabetic nephropathy in streptnzotocin-indttced diabetic rats: evaluation of various kidney-related parameters[ J]. Indian Journal of Experimental Biology,2012,50(2) :133-140.
  • 7Keller SA,Moore CC,Evans SL,et al.Activated protein C alters inflammation and protects renal function in sepsis[J].J Surg Res,2011;168(5):e103-6.
  • 8林珊,佟智颖,贾俊亚,韦丽,王希倩,商文雅.糖尿病肾病患者肾小管上皮细胞NF—κB及炎性介质表达的临床病理意义[J].中华肾脏病杂志,2010,26(1):15-19. 被引量：11
  • 9童俊容,何凤,罗正茂,张虹,王妍春,黄远航,王寅,张建林.血清NGAL和Cystatin C对糖尿病肾病早期诊断的意义研究[J].中国全科医学,2010,13(8):810-812. 被引量：46
  • 10赵芳,徐新娟,马岩萍,任容,马杰,梁晓慧.维汉两民族原发性高血压伴颈动脉粥样病变与对氧磷酶2基因多态性的相关性:同一机构3年430例报告[J].中国组织工程研究与临床康复,2010,14(20):3762-3767. 被引量：2

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中华肾脏病杂志
2010年 第2期

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