摘要
目的探讨左、右半大肠癌临床特征差异。方法总结分析经病理确诊的8551例大肠癌患者的临床资料,以结肠脾曲为界区分左、右半大肠,分别计算两者的性别、年龄、组织学类型和Duke分期的频数和比例,比较其差异。结果大肠癌分布于左半大肠和右半大肠分别占77.9%、22.1%。随着年份推移,左半大肠癌的比例从80.9%降至75.1%,右半大肠癌的比例从19.1%增至24.9%,(P<0.05);随着年龄增长,左半大肠癌的比例从79.3%下降至76.2%,右半大肠癌的比例从20.7%增至23.8%(P>0.05);右半大肠癌比例男性为21.6%(1094/5058),女性为22.7%(792/3493),(P>0.05);粘液腺癌和印戒细胞癌的比例右半大肠为18.7%(352/1886),左半大肠为10.1%(670/6665),(P<0.05);Duke分期C期和D期的比例右半大肠为48.3%(602/1246),左半大肠为42.8%(1893/4424),(P<0.05)。结论大肠癌发病部位逐渐右移,右半大肠癌恶性程度较高,晚期癌比例较高,提示应重视全结肠镜检查。
Objective To investigate the differences of clinical features of fight- and left-sided colon cancer. Methods The clinical data of 8,551 patients with colorectal cance diagnosed by pathology were collected and analysed. Left- and fight-sided colon was distinguished by the splenic flexure of the colon. After computing frequencies and proportions of sex, age, histological type and Duke＇s stage in two groups, differences were compared. Results Proportions of colorectal cancers which were distributed in left-sided colon and right-sided colon were 77.9% ,22,1%, respectively. Along with the growth of the age, proportion of left-sided colon cancer was decreased from 80.9% to 75.1%, and right-sided colon cancer was increased from 19.1% to 24.9% （P 〈 0.05）. Similarly, proportion of left-sided colon cancer was decreased from 79.3% to 76.2%, right- sided colon cancer was increased from 20.7% to 23.8% （P 〉 0.05）. In patients with fight-sided colon cancer, 21.6% （1,094/5,058） of patients was male, while 22.7%（792/3,493） was female（P 〉 0.05）. Mucinous adenocarcinomas and signet-ring cell carcinomas was 18.7% （352/1,886） in fight-sided colon cancer, and 10.1%（670/6, 665） in left-sided colon cancer （P 〈 0.05）. Proportion of Duke＇s stage C and D was 48.3%（602/1,246） in fight -sided colon cancer and 42.8%（1,893/4,424） in left -sided colon cancer （P 〈 0.05）. Conclusions Since the shifting of colorectal cancer from left-sided colon to fight-sided colon, higher malignant degree of right -sided colon cancer, and higher proportion of advanced stage, the colonoscopy should be recommended
出处
《现代消化及介入诊疗》
2010年第1期10-13,共4页
Modern Interventional Diagnosis and Treatment in Gastroenterology
基金
广东省医药科学技术科研基金(B2005132)
广东省医学科研基金(A2008754)
关键词
结直肠肿瘤
发病部位
临床特征
Colorectal carcinoma
Location
Clinical features
