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急性心肌梗死患者血浆神经肽Y的变化及意义 被引量:1

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摘要 目的研究急性心肌梗死(AMI)发病时神经肽Y(NPY)的作用及临床意义。方法用放射免疫分析法测定AMI患者胸痛发作时及治疗缓解3d后血浆中NPY浓度。结果AMI入院胸痛发作时血浆NPY浓度明显高于对照组([269.5±100.7)ng/L,(270.8±99.7)ng/L对(155.6±37.8)ng/L,P<0.010],经治疗缓解后均下降到与对照组相比无差异[(172.4±100.9)ng/L,(176.8±60.5)ng/L对(155.6±37.8)ng/L,P>0.05]。急性心梗组入院时泵功能Ⅲ~Ⅳ级者(n=5)血浆NPY浓度明显高于Ⅰ~Ⅱ级者(n=5)[(333.7±79.4)ng/L对(167.9±36.9)ng/L,P<0.05]。结论AMI患者发病时NPY增高可能是由于严重心肌缺血、剧烈胸痛引起交感神经过度兴奋及血小板释放NPY增多所致,而NPY增加进一步引起冠脉痉挛,加重心肌缺血。
出处 《中外医疗》 2010年第1期74-74,76,共2页 China & Foreign Medical Treatment
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