摘要
目的通过检测29份胃癌标本 TGF β1和 TGFβⅡ型受体的 mRNA 水平,探讨它们与胃癌浸润和转移的关联性。方法应用点杂交法和计算机灰度扫描分析组织的 mRNA 水平。结果胃癌组的 TGF βⅠmRNA 灰度均值明显高于癌旁对照组(P<0.001),浸润组或伴有淋巴结转移组分别明显高于膨胀组或无淋巴结转移组(P<0.05);而上述各组的 TGFβⅡ型受体mRNA 水平变化却与 TGFβⅠ相反,并且二者具有明显的负相关性(r=-0.697,P<0.05)。结论 TGFβ1和TGFβⅡ型受体可能在胃癌的浸润和转移过程中发挥着某种不同的作用。
Objective To investigate the relationship between the mRNA expression of TGF β1 and TGF βⅡ receptors and the invasiveness and metastatic potential of gastric carcinomas.Methods mRNA levels of TGF βⅠ and TGF βⅡ receptors were determined in 29 patients with gastric carcinoma.Gremy values of tissue mRNA were analyzed by dot blot and computer scanning.Results The Gremy value of TGF βⅠ mRNA was much higher (P<0.001) in gastric cancer group than that of control group,and it was also higher (P<0.05) in groups of infiltrating and metastatic carcinoma than that in groups of expansile or non-metastatic.On the other hand,changes of tissue TGF βⅡ receptor mRNA of all groups were opposite to those of tissue TGF βⅠ mRNA level.Moreover,Gremy value of TGF βⅠ mRNA was negatively correlated with those of TGF βⅡ receptor mRNA (r=-0.697,P<0.0- 5).Conclusion TGF βⅠ and TGF βⅡ receptor plays a different role in the infiltration and metastasis of gastric carcinomas.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1998年第6期346-348,共3页
Chinese Journal of Digestion
基金
国家自然科学基金资助
批准号:39570786
