摘要
为进一步了解Bcl - 2在基底细胞癌 (BCC)和鳞状细胞癌 (SCC)发生中的作用 ,作者应用免疫组织化学方法观察了 4例BCC和 4例SCC冰冻组织内Bcl- 2的表达。在 4例SCC中2例组织内肿瘤细胞见有明显的阳性染色 ,而BCC阳性染色主要在间质的炎细胞中 ,瘤细胞末见确切的阳性染色。作者认为这些瘤组织内Bcl- 2阳性表达不同 ,可能是不同瘤组织自身抑制肿瘤细胞凋亡的一种自动平衡反应。就本文对Bcl - 2的研究 ,还不能完全了解瘤组织内细胞凋亡抑制作用的全貌 。
In oroler to further study the role of apotosis on basal cell carcinoma(BCC)and sguamous cell carcinoma(SCC)development,the authors examined the expression of bcl-2 in 4 SCC and 4 BCC obtained from frozen tissue using immunohistochemical methods.Expression of bcl-2 in tumor cells was observed in 2 of 4 SCC but not in 4 BCC.The authors believe that the difference of bcl-2 expression in these tissues.suggests that it may represent a homeostatic response to high rats of apotosis in difference tumor tissue.In this study of bcl-2,the authors connot entirelly understand the inhibition of apotosis,as there are other genes that intervene in the regulation of apotosis.
出处
《皮肤病与性病》
1998年第4期3-4,共2页
Dermatology and Venereology
