摘要
目的通过病例对照研究人类免疫缺陷病毒(HIV)感染并发结核病(TB)死亡病例的特征。方法收集2005年1月～2009年6月在复旦大学附属上海市公共卫生临床中心住院的HIV/TB感染的死亡病例43例(病例组),同时收集同期的非HIV感染的TB死亡病例67例(对照组),采用病例对照研究的方法对两组病例进行分析。结果HIV/TB双重感染死亡病例中肺外结核、并发真菌感染、CD4+细胞≤200个.μL-1等指标明显高于对照组,痰涂片和痰培养阳性率、耐多药率、肺内存在空洞等指标明显低于对照组(P<0.05)。结论在HIV/TB双重感染的死亡病例中肺外结核多见,并发真菌感染多见,CD4+细胞<200个.μL-1多见,空洞少见,痰菌阳性率低,耐多药问题还不是目前TB/HIV双重感染死亡病例的主要问题。
Objective To compare clinical features of patients coinfected with human immunodefieiency virus （HIV） and mycobacterium tuberculosis（TB）who died during hospitalization. Methods 43 patients admitted with HIV/TB who died during hospitalization and 67 patients died of TB but no HIV simultaneously, from Shanghai Public Health Clinical Center Affiliated to Fudan University from January 2005 to June 2009 were collected. Both groups were compared by the case-control study method. Results Extra-pulmonary tuberculosis, combined with fungal infection and CD4 cell declined （≤200 cell - μL^-1 ） in HIV/TB infection group were more obvious than those in the control group （ P 〈 0.05 ） ; on the other hand, low positive rate of sputum bacteria smear and culture, high rate of multi-drug resistance and cavity in lung were significantly lower that those in the control （ P 〈 0. 05 ）. Conclusion Extra-pulmonary tuberculosis, fungal infecfons and CD4＋ cell declining （ ≤200 cell ·μL-1 ） are common to be found in HIV/TB dual infected cases who finally died. While the cavity in lungs and the positive rate of bacteria in sputum is rare to be seen. The multi-drug resistance is not the key feature to cause the death of TB/HIV dual infected patients.
出处
《医药导报》
CAS
2010年第3期295-297,共3页
Herald of Medicine
基金
国家"十一五"重大专项课题基金资助项目(基金编号:2008ZX10001-008)
上海市公共卫生重点学科建设项目(基金编号:08GWZX0103)
