摘要
为进一步探讨干燥综合征(Sjogren Syndrome,SS)涎腺损害的机理,通过对18例SS患者组和6例对照组的研究,从形态上观察到:SS组淋巴细胞浸润在3级以上的病例(n=10),其部分导管上皮和腺泡细胞有典型的细胞凋亡征象,用DNA末端标记不仅确认为这10例中细胞凋亡的存在,而且发现了另外6例也有细胞凋亡,结果与对照组有显著性差异(P<0.01)。Fas抗原检测结果:18例患者均有不同程度表达,对照组未见阳性表达。表明涎腺组织细胞凋亡可能是SS口腔病损的主要形式之一,而且与Fas抗原表达及介导有关。淋巴细胞浸润严重组(n=10)与轻微组(n=8)之间Fas抗原表达有显著性差异(P<0.01)。表明Fas表达及介导的腺体组织的细胞凋亡与淋巴细胞浸润有关。
To explore the presence of apoptosis and the expression of Fas antigen in sialaden of SJogren Syndrome (SS) .speccimens from 18 patients with SS and 6controls were studied with immunohistochemical techniques of DNA nick end labeling in 16of 18 SS cases. The result has a significane difference (P<0.01) in SS cases compared with normal subject. All of the SS patients have a positive reaction of immunohistochemical stains for antigen in ductal epithelial cells. The density of Fas antigen expressing is related to the grade of sialoadenitis. These findings, suggest that apoptosis may be a characteristic of pathological injuries in sialaden of SSand may be related to the expression and intervenction of Fas antigen.
出处
《现代口腔医学杂志》
CAS
CSCD
1998年第4期268-270,共3页
Journal of Modern Stomatology
