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高压氧配合常规综合治疗病毒性脑炎患儿的疗效及对脑脊液IL-6和TNF-α与CRP水平的影响 被引量:5

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摘要 【目的】观察高压氧配合常规综合治疗病毒性脑炎患几的临床疗效及对脑脊液肿瘤坏死因子-α(TNF—α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平的影响。【方法】60例病毒性脑炎患儿按不同治疗方法分为对照组和实验组各30例,对照组予以常规综合治疗,实验组在对照组基础上加用高压氧治疗。分别在病程d3、d7、d14行腰椎穿刺收集脑脊液,检测TNF-α、IL-6和CRP水平。【结果】实验组总有效率(90.00%)显著高于对照组(73.33%)(P〈0.05),两组患儿病程d3时TNF-α、IL-6和CRP水平比较差异无统计学意义(P〉0.05),随病程和治疗后呈逐渐下降趋势,d7和d14时实验组TNF-α和CRP值显著低于对照组(P〈0.05),IL-6值显著高于对照组(P〈0.05)。【结论】高压氧治疗可能通过调节TNF-α、IL-6、CRP表达而改善病毒性脑炎患儿预后。
出处 《医学临床研究》 CAS 2010年第2期317-319,共3页 Journal of Clinical Research
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