摘要
目的:探讨多发性骨髓瘤(MM)的发病机制。方法:采用免疫学方法检测了21例MM患者血浆中肿瘤坏死因子α(TNFα)含量,同时检测了16例MM患者的红细胞免疫功能。结果:进展期、稳定期MM组及正常对照组的TNFα含量无显著性差异;MM患者的红细胞C_3b受体花环率和红细胞免疫复合物花环率均显著低于正常对照组。结论:MM患者可能存在单核-巨噬系统和红细胞免疫功能缺陷。
Objective:To explore factors in the pathogenesis of multiple myeloma(MM).Methods:The plasma level of tumor necrosis factor-alpha(TNFα)measured by immunoassay in 21 MM patients,and red cell immunologic function was assayed in 16 patients. Results:There was no difference in TNFαlevels among patients with either fulrninant MM or stable MM and normal controls.The rosette formation rate of red cell C_3bR and red cell immune complex was significantly lower in MM patients than in the controls. Conclusion: MM patients might have impaired monocyte-phagocyte system and red cell immune function.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1998年第11期563-565,共3页
Chinese Journal of Hematology
