摘要
目的探讨高敏C反应蛋白和颈动脉粥样硬化的关系。方法选取在神经内科住院的患者225例(其中脑梗塞患者133例),排除了应激、炎症、自身免疫性疾病等影响高敏C反应蛋白水平的疾病,全部患者行颈部血管彩超检测,观察颈动脉内膜-中膜厚度、斑块的检出情况及斑块评分、管腔的狭窄率,作为评价颈动脉粥样硬化的指标。根据血管彩超的检查结果分为颈动脉粥样硬化组和对照组。用微粒子透射增强免疫法(超敏)检测血浆高敏C反应蛋白的水平。分别比较颈动脉粥样硬化组与对照组高敏C反应蛋白水平的差别,分析高敏C反应蛋白和颈动脉内膜-中膜厚度、斑块评分之间的关系。结果颈动脉粥样硬化组(130例)与对照组(95例)比较,二者之间的高敏C反应蛋白存在明显差异(P<0.05);偏相关分析显示,高敏C反应蛋白与颈动脉内膜-中膜厚度及斑块评分成正相关,相关系数分别为0.4807和0.3024。结论颈动脉粥样硬化组较对照组高敏C反应蛋白水平高,高敏C反应蛋白与颈动脉粥样硬化的严重程度成正相关。
Aim To observe high-sensitive C-reactive protein（hs-CRP） expression in carotid atherosclerosis.Methods All enrolled patients were evaluated for carotid atherosclerosis by ultrasonography and detected for the level of hs-CRP in blood plasma.The hs-CRP content in carotid atherosclerosis group was compared with control group.The relationship between hs-CRP and carotid interia-media thickness（IMT）/carotid plaque scores was analysed.Results The level of hs-CRP（4.40 mg/L,0.20~16.91 mg/L） in carotid atherosclerosis group was higher than that in control group（1.07 mg/L,0.20~13.00 mg/L）（P0.05）.Partial correlation analysis of hs-CRP and carotid intima-media thickness/plaque scores showed positive correlation,and the partial coefficients were 0.4807 and 0.3024 separately（P0.05）.Conclusion The hs-CRP level is higher in carotid atherosclerosis group compared with that in control patients.The level of hs-CRP is positively correlated with the severity of carotid atherosclerosis.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2009年第12期1021-1023,共3页
Chinese Journal of Arteriosclerosis
关键词
高敏C反应蛋白
动脉粥样硬化
彩超
斑块
High-sensitive C-reactive Protein
Atherosclerosis
Ultrasonography
Plaque
