摘要
目的:了解尖锐湿疣(condyloma acuminatum,CA)患者的人乳头状瘤病毒(human papilloma virus,HPV)感染情况。方法:应用荧光定量PCR技术对68例CA患者和160例CA亚临床患者进行HPV6型、11型、16型和18型检测。结果:男性患者和女性患者的HPV阳性率分别为78.99%和77.78%,差异无统计学意义(P>0.05);CA患者疣体组织和亚临床患者皮损标本的检出率分别为95.59%和71.25%,差异有统计学意义(P<0.01);179例HPV阳性病例中,感染HPV6型、11型占76.54%,感染HPV16型、18型占8.94%,HPV6型、11型、16型和18型混合感染占14.52%。结论:CA患者HPV感染无性别差异,且疣体组织的检出率高于其他皮损标本,HPV感染以低危型的6型和11型为主。
Objective：To comprehend the infect condition of human papilloma virus （HPV） in patients with condyloma acuminatum （CA）. Methods：The real-time FQ-PCR method was established to detect HPV type 6,11,16 and 18 in 68 samples from patients with condyloma acuminatum and 160 samples from subclinical patients. Results：The positive rates of male and female were 78.99% and 77.78%, respectively, there was no stastical significance （P 〉 0. 05 ）. Detection rates of CA tissues and subclinical tissues were 95.59% and 71.25% ,respectively, with the stastical significance （ P 〈 0.01 ）. Among the 179 HPV positive patients,76.54% were infected with HPV type 6 and type 11, 8.94% were infected with HPV type 16 and type 18, 14.52% were mixed infection with HPV type 6,11,16 and 18. Conclusions：The HPV infective rate in male is as same as in female; and the detection rate of CA is higher than in other samples; HPV type 6 and type 11 infection are the main reasons in our region.
出处
《蚌埠医学院学报》
CAS
2010年第2期178-180,共3页
Journal of Bengbu Medical College
关键词
尖锐湿疣
人乳头状瘤病毒
荧光定量聚合酶链反应
condyloma acuminatum
human papilloma virus
fluorescent quantitation polymerase chain reaction
