摘要
目的探讨促性腺激素释放激素激动剂（GnRH-a）短方案超排卵前，使用口服避孕药预治疗对体外受精胚胎移植（IVF—ET）妊娠的影响。方法分析186个GnRH—a短方案IVF-ET周期治疗情况。83个周期在短方案超排卵前口服避孕药1个周期（OCP组），103个启动超排卵前未使用过任何药物（非OCP组）。结果OCP组患者卵泡成熟日的子宫内膜厚度低于非OCP组（8．7mm比9．5mm P〈0．05），周期取消率高于非OCP组（24．1％比12．6％，P〈0．05）。OCP组的胚胎种植率、持续妊娠率均低于非OCP组，分别为（11．2％比19．9％，P〈0．05）（12．7％比27．8％，P〈0．05）。结论GnRH-a短方案超排卵前OCP的使用降低了IVF患者的胚胎种植率和持续妊娠率。
Objective To determine the link between oral contraceptive pill （OCP） use and IVF/ ICSI treatment outcomes under a short GnRH agonist protocol. Methods A total of 186 patients （one cycle each patient） received a short GnRH agonist protocol at Day 2 of menstrual cycle for IVF/ICSI. Among them, 83 patients took OCP pre-treatment prior to the stimulation protocol （OCP group） and 103 patients received no OCP （ non-OCP group）. The triggering of final oocyte maturation was performed with 10 000 IU of hCG. Results The ongoing pregnancy rates per started cycle in the non-OCP group and OCP group were 27.8% and 12.7% （P 〈 0. 05 ） respectively. The clinical pregnancy rate and embryo implantation rate were significantly reduced in OCP group （clinicaJ pregnancy rate 16.5% , implantation rate 11.2% ） as compared with non-OCP group （32. 2% and 19. 9% , P 〈0. 05）. The endometrium on hCG day was thicker in non- OCP group than OCP group （ 9. 5 mm vs 8.7 mm, P 〈 0. 05 ）. Conclusion Pretreatment with OCP, as compared with initiation of stimulation at Day 2 of cycle in patients treated with GnRH-a short protocol antagonist appears to be associated with a significant difference in ongoing pregnancy rates per started cycle.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2010年第7期454-457,共4页
National Medical Journal of China
基金
北京大学医学部“985工程”二期学科建设资助（985-2-015-24）
关键词
口服避孕药
GNRH
超排卵
体外受精
Oral eontracepative pill
GnRH agonist
Ovarian stimulation
IVF
