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关注肌萎缩侧索硬化的生物标志物 被引量：1

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摘要 肌萎缩侧索硬化（amyotrophic lateral sclerosis，ALS）是一种进行性致死性疾病，80％～90％的患者于发病后3～5年内死亡。目前其具体发病机制仍不明了，对此病的诊断仍依赖于临床，而且从患者出现症状到明确诊断有明显延迟性和较高的误诊率，常使我们不能早期进行有效的干预治疗。这也是为什么许多药物在ALS的基础研究中有效，而临床试验却无效的原因之一。
作者 张俊 樊东升
机构地区 北京大学第三医院神经内科
出处 《中华神经科杂志》 CAS CSCD 北大核心 2010年第2期81-83,共3页 Chinese Journal of Neurology
关键词 肌萎缩侧索硬化 生物标志物 临床试验 致死性疾病 发病机制 干预治疗 进行性 发病后
分类号 R744.8 [医药卫生—神经病学与精神病学]
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参考文献21

  • 1Turner MR, Kiernan MC, Leigh PN, et al. Biomarker in amyotrophic lateral sclerosis. Lancet Neurol, 2009, 8: 94-109.
  • 2Zoccolella S, Beghi E, Palagano G, et al. Predictors of delay in the diagnosis and clinical trim entry of amyotrophic lateral sclerosis patients: a population-based study. J Neurol Sci, 2006, 250: 45- 49.
  • 3Swash M, Ingram D. Preclinical and subclinical events in motor neuron disease. J Neurol Neurosurg Psychiatry, 1988, 51: 165- 168.
  • 4Turner MR, Parton MJ, Shaw CE, et al. Prolonged survival in motor neuron disease: a descriptive study of the King' s database 1990-2002. J Neurol Neurosurg Psychiatry, 2003, 74: 995-997.
  • 5Scott S, Kranz JE, Cole J, et al. Design, power, and interpretation of studies in the standard murine model of ALS. Amyotroph Lateral Scler, 2008, 9: 4-15.
  • 6Ryberg H, Bowser R. Protein biomarkers for amyotrophic lateral sclerosis. Expert Rev Proteomics, 2008, 5 : 249-262.
  • 7Ono S, Hu J, Shimizu N, et al. Increased interleukin-6 of skin and serum in amyotrophic lateral sclerosis. J Neurol Sci, 2001, 187 : 27-34.
  • 8Hosback S, Hardiman O, Nolan CM, et al. Circulating insulin- like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple sclerosis. Growth Horm IGF Res, 2007, 17: 472-479.
  • 9Neumann M, Sampathu DM, Kwong LK, et all. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science, 2006, 314 : 130-133.
  • 10Rothstein JD, Tsai G, Kuncl RW, et al. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann Neurol, 1990, 28: 18-25.

二级参考文献68

  • 1宋红松,张俊,樊东升,郑菊阳,张朔,徐迎胜,康德瑄.自动递增刺激法运动单位估数及其对肌萎缩侧索硬化的临床意义[J].中华神经科杂志,2004,37(6):526-528. 被引量：8
  • 2王惠芳,樊东升,张俊,张华纲,王晓飞,鲁明,康德宣.肌萎缩侧索硬化症的院前误诊分析[J].中国现代神经疾病杂志,2005,5(4):240-243. 被引量：15
  • 3Ringel SP, Murphy JR, Alderson MK, et al. The natural history of amyotrophic lateral sclerosis. Neurology, 1993, 43: 1316- 1322.
  • 4Goodin DS, Rowley HA, Olney RK. Magnetic resonance imaging in amyotrophic lateral sclerosis. Ann Neurol, 1988, 23:418-420.
  • 5Oba H, Araki T, Ohtomo K, et al. Amyotrophic lateral sclerosis: T2 shortening in motor cortex at MR imaging. Radiology, 1993, 189 : 843-846.
  • 6Cheung G, Gawel M J, Cooper PW, et al. Amyotrophic lateral sclerosis: correlation of clinical and MR imaging findings. Radiology, 1995, 194: 263-270.
  • 7Block W, Karitzky J, Traber F, et al. Proton magnetic resonance spectroscopy of the primary motor cortex in patients with motor neuron disease: subgroup analysis and follow-up measurements. Arch Neurol, 1998, 55 : 931-936.
  • 8Pohl C, Block W, Traber F, et al. Proton magnetic resonance spectroscopy and transcranial magnetic stimulation for the detection of upper motor neuron degeneration in ALS patients. J Neurol Sci, 2001, 190: 21-27.
  • 9Rooney WD, Miller RG, Gelinas D, et al. Decreased Nacetylaspartate in motor cortex and corticospinal tract in ALS. Neurology, 1998, 50: 1800-1805.
  • 10Bowen BC, Pattany PM, Bradley WG, et al. MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis. AJNR Am J Neuroradiol, 2000, 21 : 647-658.

共引文献19

同被引文献12

  • 1Bartel DP. MicroRNAs : genomics, biogenesis, mechanism, and function. Cell, 2004, 116 : 281-297.
  • 2Junn E, Mouradian MM. MicroRNAs in neurodegenerative diseases and their therapeutic potential. Pharmacol Ther, 2012, 133:142-150.
  • 3Mo MH, Chen L, Fu Y, et al. Cell-free circulating miRNA biomarkers in cancer. J Cancer, 2012, 3: 432-448.
  • 4Karolina DS, Tavintharan S, Armugam A, et al. Circulating miRNA profiles in patients with metabolic syndrome. J Clin Endocrinol Metab, 2012,97 :E2271-2276.
  • 5Rowland LP. Diagnosis of amyotrophic lateral sclerosis. J Neurol Sci, 1998,160Suppl1 : S6-24.
  • 6Vickers KC, Remaley AT. Lipid-based carriers of microRNAs and intercellular communication. Curr Opin Lipidol, 2012, 23 : 91-97.
  • 7Duttagupta R, Jiang R, Gollub J, et al. Impact of cellular miRNAs on circulating miRNA biomarker signatures. PLoS One, 2011, 6: e20769.
  • 8Morin RD, O' Connor MD, Griffith M, et al. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res, 2008, 18: 610- 621.
  • 9Tian S, Huang S, Wu S, et al. MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3' untranslated region. Biochem Biophys Res Commun, 2010, 396 : 435-439.
  • 10Niemoeller OM, Niyazi M, Corradini S, et al. MicroRNA expression profiles in human cancer cells after ionizing radiation. Radiat Oncol, 2011, 6: 29.

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中华神经科杂志
2010年 第2期

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