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盐酸决奈达隆合成路线图解 被引量:13

Graphical Synthetic Routes of Dronedarone Hydrochloride
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摘要 盐酸决奈达隆(dronedarone hydrochloride,1盐酸盐),化学名为2-正丁基.3.[4-(3-二正丁基氨基丙氧基)苯甲酰基]-5-甲磺酰胺基苯并呋喃盐酸盐,是由法国赛诺菲-安万特公司开发的极化抑制剂,2009年7月首次在美国上市,临床主要用于治疗心律失常。本品能有效降低心房纤颤或心房扑动患者心血管事件住院风险,
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2010年第2期148-151,共4页 Chinese Journal of Pharmaceuticals
基金 国家"重大新药创制"科技重大专项资助(2009ZX09301-007)
  • 相关文献

参考文献14

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  • 2Biard M. 2-Butyl-3- (4- [3- (dibutylamino) propoxy] - benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof: WO, 2002048078 [P]. 2002-06-20. (CA 2002, 137: 33204).
  • 3Gutman AL, Nisnevich G, Yudovitch L. Process for the preparation of dronedarone: WO, 2003040120 [P]. 2003-05-15. (CA 2003, 138: 385296).
  • 4杨利民.一种决奈达隆关键中间体的新的制备方法:中国,101153012[P].2008-04-02.
  • 5Gubin J, Lucchetti J, Inion H, benzofurans, benzothiophenes, ind cardiovascular agents: EP, 471609 et al. Preparation of oles, and indolizines as [P]. 1992-12-19. (CA1992, 117: 26336).
  • 6Diouf O, Durand T, Lemeune S, et al. Process for preparation of 2- (n-butyl) -3- (4-hydroxybenzoyl) -5-nitrobenzofuran starting from 4-nitrophenol: WO, 2008139057 [P]. 2008-11-20. (CA 2008, 149: 556432).
  • 7Durand T, Diouf O, Lemeune S, et al. Process for preparation of 2- (n-butyl) -5-nitrobenzofuran from 1-halogeno-4- nitrobenzenes and 1-hexyn-3-ol via Claisen rearrangement and intramol cyclization: WO, 2008152217 [P]. 2008-12-18. (CA2008, 150: 35218).
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  • 10Schlama T. Method for preparing a benzofuran or benzothiophene compound: WO, 2001029019 [P]. 2001-04-26. (CA2001, 134: 311100).

二级参考文献11

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共引文献4

同被引文献73

  • 1张杰,张楠,葛海涛.心房颤动治疗药物决奈达隆[J].世界临床药物,2009,30(12):765-768. 被引量:6
  • 2吕峰,刘玉婷,邹竞,张大德,姚祖光.DIAR黄成色剂的合成[J].华东理工大学学报(自然科学版),2005,31(2):180-183. 被引量:2
  • 3杨利民.一种决奈达隆关键中间体的新的制备方法:中国,101153012[P].2008-04-02.
  • 4Walsh S.FDA approves Multaq to treat heart rhythm disorder[EB/OL].[2009-07-021.http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm 170276.htm.
  • 5Gubin J,Lucchetti J,Inion H,et al.Preparation of benzofurans,benzothiophenes,indoles,and indolizines as cardiovascular agents:EP,471609[P].1992-12-19.(CA 1992,117:26336).
  • 6Biard M.2-Butyl-3-(4-[3-(dibutylamino) propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof.WO,2002048078[P].2002-06-20.(CA 2002,137:33204).
  • 7Gutman AL,Nisnevich G,Yudovitch L.Process for the preparation of dronedarone:WO,2003040120[P].2003-05-15.(CA 2003,138:385296).
  • 8Fino N,Leroy C.A process for the preparation of 2-butyl-5-[methanesulfonamido]benzofuran as an intermediate for the synthesis of dronedarone:WO,2002048132[P].2002-06-20.(CA 2002,137:33205).
  • 9FDA. FDA approves Multaq to treat heart rhythm disorder [EB/OL]. [2009-07-02]. http://www.fda.gov/NewsEvents/ Newsroom/PressAnnouncements/ucm 170276.htm.
  • 10Zimetbaum PJ. Dronedarone for atrial fibrillation--an odyssey [J]. NEnglJMed, 2009, 360 (18):1811-1813.

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二级引证文献44

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