摘要
建立了HPLC法同时测定丙烯酸酯压敏胶中三种残留单体——乙酸乙烯酯、丙烯酸乙酯和丙烯酸正丁酯的含量。采用C18色谱柱,流动相为乙腈-水(40:60),检测波长210nm。乙酸乙烯酯、丙烯酸乙酯、丙烯酸正丁酯分别在0.04～20、0.04～20、0.2～100μg/ml浓度范围内线性关系良好,平均回收率为99.6%、100.8%和99.4%,RSD小于2%;日内、日间RSD小于3%和5%。
An HPLC method was established for the determination of vinyl acetate, ethyl acrylate and n-butyl acrylate, the residual monomers in acrylic pressure sensitive adhesive （PSA）. A C18 column was used with the mobile phase of acetonitrile-water （40 ： 60） at the detection wavelength of 210 nm. The calibration curves of vinyl acetate, ethyl acrylate and n-butyl acrylate were linear in the concentration ranges of 0.04 - 20, 0.04 - 20, 0.2 - 100 μg/ml. The average recoveries were 99.6%, 100.8% and 99.4%, respectively, with RSDs less than 2%. The RSDs of intra- and inter-day were less than 3 % and 5 %.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2010年第2期120-122,共3页
Chinese Journal of Pharmaceuticals
关键词
丙烯酸压敏胶
残留单体
高效液相色谱
测定
acrylic pressure sensitive adhesive （acrylic PSA）
residual monomers
HPLC
determination
